An integrated machine learning-based prognostic model in head and neck cancer using the systemic inflammatory response index and correlations with patient reported financial toxicity.

Journal: Research square
Published Date:

Abstract

OBJECTIVE: To investigate the prognostic utility of systemic inflammatory response index (SIRI) as a biological readout of stress associated immune modulation in head and neck cancer patients who underwent radiation therapy.

Authors

  • Anurag K Singh
    Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
  • Sung Jun Ma
    Department of Radiation Oncology, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, 460 West 10th Avenue, Columbus, OH 43210, USA.
  • Dukagjin Blakaj
    Department of Radiation Oncology, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, 460 West 10th Avenue, Columbus, OH, 43210, USA.
  • Simeng Zhu
    Department of Radiation Oncology, Henry Ford Health Systems, Detroit, MI, United States of America.
  • Neil D Almeida
    Department of Radiation Medicine Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Andrew Koempel
    Department of Radiation Oncology, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, 460 West 10th Avenue, Columbus, OH, 43210, USA.
  • Guangwei Yuan
    Department of Biostatistics and Bioinformatics Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Grace Wang
    Gambling & Addictions Research Centre, Auckland University of Technology, Auckland, New Zealand.
  • Kimberly Wooten
    Department of Head and Neck Surgery Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Vishal Gupta
    Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai Medical School, New York, New York.
  • Ryan McSpadden
    Department of Head and Neck Surgery Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Moni A Kuriakose
    Integrated Head and Neck Oncology Program, Mazumdar Shaw Medical Foundation, Narayana Health City, Bommsandra Industrial Area, Bangalore, 99, India. makuriakose@gmail.com.
  • Michael R Markiewicz
    Professor and Chair, Department of Oral and Maxillofacial Surgery, Associate Dean for Hospital Affairs, School of Dental Medicine, University at Buffalo, Clinical Professor, Department of Neurosurgery, Divison of Pediatric Surgery, Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, Co-Director- Craniofacial Center of Western New York, John Oishei Children's Hospital, Attending Surgeon, Department of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY. Electronic address: mrm25@buffalo.edu.
  • Song Yao
    Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Wesley L Hicks
    Professor and Chair, Department of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
  • Mukund Seshadri
    Department of Oral Oncology Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Elizabeth A Repasky
    Department of Immunology Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Elizabeth G Bouchard
    Department of Radiation Medicine Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Mark K Farrugia
    Department of Radiation Medicine Roswell Park Comprehensive Cancer Center Elm and Carlton Streets Buffalo, NY 14203. USA.
  • Han Yu
    1Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University, Singapore, 639798 Singapore.

Keywords

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