The integrated single-cell analysis interpret the lactate metabolism-driven immune suppression in triple-negative breast cancer.

Journal: Discover oncology
Published Date:

Abstract

BACKGROUND: Individuals with triple-negative breast cancer (TNBC) exhibit elevated lactate levels, which offers a valuable lead for investigating the molecular mechanisms underlying the tumor microenvironment (TME) and identifying more efficacious treatments.

Authors

  • Xinhai Gao
    Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, 999078, Macao, China.
  • Tianhua Wang
    Heilongjiang University, Harbin 150080, China.
  • Cun Liu
    Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, PR China. Electronic address: liucun@issas.ac.cn.
  • Ye Li
    Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Haikou 571010, People's Republic of China; Key Laboratory of Monitoring and Control of Tropical Agricultural and Forest Invasive Alien Pests, Ministry of Agriculture, Haikou 571010, People's Republic of China.
  • Wenfeng Zhang
    College of Traditional Chinese Medicine, Shandong Second Medical University, 261000, Weifang, Shandong, China.
  • Minpu Zhang
    Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, 999078, Macao, China.
  • Yan Yao
    Automation College, Beijing University of Posts and Telecommunications, Beijing, China.
  • Chundi Gao
    College of Traditional Chinese Medicine, Shandong Second Medical University, 261000, Weifang, Shandong, China.
  • Ruijuan Liu
    Department of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261000, Shandong, China.
  • Changgang Sun
    College of Traditional Chinese Medicine, Shandong Second Medical University, 261000, Weifang, Shandong, China. scgdoctor@126.com.

Keywords

No keywords available for this article.