Progestin prime ovarian stimulation provides comparable outcomes to GnRH antagonist in donor cycles with vitrified oocytes.

Journal: Fertility and sterility
Published Date: May 20, 2025

Abstract

OBJECTIVE: To compare the effectiveness and safety of Medroxyprogesterone Acetate (MPA) and Gonadotropin-Releasing Hormone antagonist (GnRHant) protocols in vitrified donor oocyte cycles and expand the current evidence on their clinical outcomes DESIGN: Retrospective cohort study SUBJECTS: This study included 14,981 recipients who received vitrified oocytes coming from 3,599 donors stimulated with MPA and 4,998 donors stimulated with GnRHant.

Authors

  • Lucía Murria
    IVIRMA Global Research Alliance - IVIRMA Valencia, 46015 Valencia, Spain; IVIRMA Global Research Alliance - IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain. Electronic address: lucia.murria@ivirma.com.
  • Juan Giles
    IVIRMA Global Research Alliance - IVIRMA Valencia, 46015 Valencia, Spain; IVIRMA Global Research Alliance - IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain.
  • Lorena Bori
    IVI-RMA Valencia, Valencia, Spain. Electronic address: lorena.bori@ivirma.com.
  • José Remohí
    IVIRMA Global Research Alliance - IVIRMA Valencia, 46015 Valencia, Spain; IVIRMA Global Research Alliance - IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain.
  • Ana Cobo
    IVIRMA Global Research Alliance - IVIRMA Valencia, 46015 Valencia, Spain; IVIRMA Global Research Alliance - IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain.

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