Computational analysis of DEHP's oncogenic role in colorectal cancer.

Journal: Discover oncology
Published Date: May 21, 2025

Abstract

BACKGROUND: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with many patients diagnosed at advanced stages. Current treatments, including surgery, chemotherapy, and targeted therapies, face limitations due to tumor metastasis and chemoresistance. Di-(2-ethylhexyl) phthalate (DEHP), a widely-used plasticizer, has been linked to various cancers, including CRC, through mechanisms such as metabolic reprogramming and inflammation. However, the direct relationship between DEHP and CRC requires further elucidation.

Authors

  • Zhou Zhu
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China. Electronic address: zhouzhu@hust.edu.cn.
  • Jian Qin
    College of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
  • Chungang He
    Department of Colorectal and Anal Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
  • Shuangyou Wang
    Department of Colorectal and Anal Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
  • Yaolin Lu
    Department of Colorectal and Anal Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
  • Shuai Wang
    Department of Intensive Care Unit, China-Japan Union Hospital of Jilin University, Changchun, China.
  • Xiaogang Zhong
    Department of Colorectal and Anal Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China. xiaogangzhong@163.com.

Keywords

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