RhDnostics: A Machine Learning-Based Predictive Algorithm Model for RhD-Negative and DEL Blood Group Screening.

Journal: The journal of applied laboratory medicine
Published Date: May 30, 2025

Abstract

BACKGROUND: The D-elution (DEL) phenotype is serologically mislabeled as Rh-negative because of the very low amount of D antigen on red blood cells. The adsorption-elution test and genotyping are recommended tests for confirmation. However, turnaround time and the availability of instruments, reagents, and budget, as well as technical issues are challenging factors of DEL identification in laboratory practice and patient safety.

Authors

  • Meechoke Choodoung
    Department of Mathematics, Faculty of Science, Mahidol University, Bangkok, Thailand.
  • Charuporn Promwong
    Blood Bank and Transfusion Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand.
  • Ketsaraporn Wongba
    Blood Bank and Transfusion Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand.
  • Arunsri Choodoung
    Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
  • Usanee Kerdpin
    Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok, Thailand.
  • Peeradech Thichanpiang
    Division of Occupational Therapy, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand.
  • Chotiros Plabplueng
    Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Salaya, Thailand.
  • Yann Fichou
    University of Brest, Inserm, EFS, UMR1078, GGB, Brest, France.
  • Pornlada Nuchnoi
    Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Salaya, Thailand.

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