Anoikis in hepatocellular carcinoma: genetic alterations and immune microenvironment insights from single-cell and computational analysis.

Journal: Discover oncology
Published Date: May 31, 2025

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by high heterogeneity, and its molecular features and microenvironment complexity contribute to varied patient prognoses. Anoikis, a form of programmed cell death, is considered closely linked to the development and progression of liver cancer. This study aimed to analyze the cellular heterogeneity of HCC using single-cell sequencing and to construct an anoikis-related prognostic model for predicting patient outcomes.

Authors

  • Bing Zhou
    Cooperative Innovation Center of Internet Healthcare, Zhengzhou University, Zhengzhou 450001, China.
  • Jialing Zhang
    Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian City, 223300, Jiangsu, People's Republic of China. zhangjialingone@163.com.
  • Mingfeng Guo
    Department of EICU, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China. hayygmf@126.com.

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