Heart rate variability in patients with cardiovascular diseases.

Journal: Progress in cardiovascular diseases
Published Date: Jun 10, 2025

Abstract

Heart rate variability (HRV) has been reported to predict overall mortality and the risk of cardiovascular disease events in patients, including those with heart failure. However, inconsistent methods of recording and analyzing HRV parameters, along with a lack of randomized data substantiating its clinical efficacy and potential to guide treatment decisions for improved patient outcomes, have limited its use in clinical settings. With the advancements in technologies such as artificial intelligence and machine learning, and emergence of ablation procedures that can alter autonomic function, this article re-explores HRV assessment methods, their potential for clinical application, the issues encountered in using them in clinical research, and potential approaches to studying HRV in the future (Graphical Abstract).

Authors

  • Muhammad Shahzeb Khan
    Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
  • Syed Sarmad Javaid
    Department of Medicine, University of Mississippi Medical center, MS, USA.
  • Robert J Mentz
    Division of Cardiology, Duke University Medical Center, Durham, NC.
  • JoAnn Lindenfeld
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Hau-Tieng Wu
    Mathematics, University of Toronto, Toronto, Ontario, Canada.
  • Jürgen H Prochaska
    Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
  • Jens Brock Johansen
    Department of Cardiology, Odense University Hospital, Odense, Denmark.
  • Philipp S Wild
    Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. philipp.wild@unimedizin-mainz.de.
  • Dominik Linz
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. dominik.linz@gmx.de.
  • Wilfried Dinh
    Bayer Pharmaceuticals, Research and Early Development Precision Medicine/University Witten/Herdecke, Witten, Germany.
  • Marat Fudim
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals