Palmitoylation regulators drive the progression of clear cell renal cell carcinoma through Inhibition of cuproptosis: insights into the role of ZDHHC18.

Journal: Cancer cell international
Published Date:

Abstract

BACKGROUND: Protein palmitoylation is a reversible post-translational modification that increases protein hydrophobicity, which can affect protein localization, stability, and function. Although palmitoylation is frequently observed in various cancers, the specific mechanisms by which it influences clear cell renal cell carcinoma (ccRCC) are still not well understood.

Authors

  • Wei Xu
    College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471023 China.
  • Xiao-Chao Chen
    Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Yang Wang
    Department of General Surgery The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology Kunming China.
  • Jian-Chun Chen
    Department of Urology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, 215200, China.
  • Zhi-Jun Cao
    Department of Urology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, 215200, China.
  • Ru Huang
    School of Information Science & Engineering, East China University of Science and Technology, Shanghai 200237, China.
  • Chao Chen
    Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Dao-Rong Hou
    Key Laboratory of Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, 211166, China. houdaorong@njmu.edu.cn.
  • Min-Jun Jiang
    Department of Urology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, 215200, China. xcywj513@126.com.
  • Chen Xu
    Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Keywords

No keywords available for this article.