Joint fusion of sequences and structures of drugs and targets for identifying targets based on intra and inter cross-attention mechanisms.

Journal: BMC biology
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Accurately identifying targets not only guides treatments for diseases with unclear pathogenic mechanisms, but also reduces pharmaceutical costs and accelerates drug development timelines. However, the primary challenge in targets identification currently lies in the low accuracy of existing computational methods.

Authors

  • Xin Zeng
    Electrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.
  • Guang-Peng Su
    College of Mathematics and Computer Science, Dali University, Dali, 671003, China.
  • Wen-Feng Du
    College of Mathematics and Computer Science, Dali University, Dali, 671003, China.
  • Bei Jiang
    Clinical School of the Second People's Hospital, Tianjin Medical University, Tianjin, China.
  • Yi Li
    Wuhan Zoncare Bio-Medical Electronics Co., Ltd, Wuhan, China.
  • Zi-Zhong Yang
    Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, College of Pharmacy, Dali University, Dali, 671000, China. yangzzh69@163.com.

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