Association of urinary metal elements with sarcopenia and glucose metabolism abnormalities: Insights from NHANES data using machine learning approaches.

Journal: Ecotoxicology and environmental safety
Published Date: Jun 5, 2025

Abstract

BACKGROUND: Sarcopenia, a condition marked by the decline of skeletal muscle mass and function, is prevalent in the elderly and closely linked to abnormal glucose metabolism, particularly type 2 diabetes. Hyperglycemia can increase the formation of advanced glycation end-products (AGEs) in muscle proteins, impairing muscle function. Additionally, deficiencies in trace minerals are associated with the development of sarcopenia.

Authors

  • Xinmin Jin
    Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, China.
  • Lei Li
    Department of Thoracic Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Xiaoyan Hu
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Pengfei Bi
    Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
  • Song Zhang
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Qian Wang
    Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China.
  • Zhongwei Xiao
    Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
  • Hua Yang
  • Tongtong Liu
    Department of Electronic Engineering, Fudan University, Shanghai, China.
  • Lifang Feng
    Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
  • Jinhuan Wang
    Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266000, China. Electronic address: 1582751647@qq.com.

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