Type of pre-existing chronic conditions and their associations with Merkel cell carcinoma (MCC) treatment: Prediction and interpretation using machine learning methods.

Journal: PloS one
Published Date:

Abstract

OBJECTIVE: This study examined the prevalence of pre-existing chronic conditions and their association with the receipt of specific cancer-directed treatments among older adults with incident primary Merkel Cell Carcinoma (MCC) using novel predictive and interpretable machine learning methods.

Authors

  • Yves Paul Vincent Mbous
    Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Zasim Azhar Siddiqui
    Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, Morgantown.
  • Murtuza Bharmal
    AstraZeneca, Oncology, Outcomes Research, Boston, Massachusetts, United States of America.
  • Traci LeMasters
    Department of Pharmaceutical Systems and Policy, West Virginia University School of Pharmacy, Robert C. Byrd Health Sciences Center [North], P.O. Box 9510, Morgantown, WV, 26506-9510, USA. Electronic address: traci.lemasters@hsc.wvu.edu.
  • Joanna Kolodney
    Department of Hematology/Oncology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America.
  • George A Kelley
    Department of Epidemiology and Biostatistics, School of Public Health, West Virginia University, Morgantown, West Virginia, United States of America.
  • Khalid Kamal
    Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Usha Sambamoorthi
    Department of Pharmacotherapy, College of Pharmacy, "Vashisht" Professor of Disparities, Health Education, Awareness & Research in Disparities (HEARD) Scholar, Texas Center for Health Disparities, University of North Texas Health Sciences Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA. Electronic address: usha.sambamoorthi@unthsc.edu.