Novel protocol for metabolomics data normalization and biomarker discovery in human tears.

Journal: Clinical chemistry and laboratory medicine
Published Date: Mar 19, 2025

Abstract

OBJECTIVES: Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol for normalizing metabolomic data from human tears, enhancing its potential for biomarker identification.

Authors

  • Joan Serrano-Marín
    Molecular Neurobiology Laboratory, Universitat de Barcelona, Barcelona, Spain.
  • Silvia Marin
    Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain.
  • Alberto Iglesias
    Molecular Neurobiology Laboratory, Universitat de Barcelona, Barcelona, Spain.
  • Jaume Lillo
    Molecular Neurobiology Laboratory, Universitat de Barcelona, Barcelona, Spain.
  • Claudia Garrigós
    Molecular Neurobiology Laboratory, Universitat de Barcelona, Barcelona, Spain.
  • Toni Capó
    Molecular Neurobiology Laboratory, Universitat de Barcelona, Barcelona, Spain.
  • Irene Reyes-Resina
    CiberNed, Network Center for Neurodegenerative Diseases, Spanish National Health Institute Carlos III (ISCIII), Madrid, Spain.
  • Hanan Awad Alkozi
    Department of Optometry, College of Applied Medical Sciences, Qassim University, Almulida, Qassim, Saudi Arabia.
  • Marta Cascante
    Department of Biochemistry and Molecular Biomedicine & Institute of Biomedicine of Universitat de Barcelona, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
  • Juan Sánchez-Navés
    Department of Ophthalmology, Oftalmedic and I.P.O. Institute of Ophthalmology, Palma de Mallorca, Spain.
  • Rafael Franco
    Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain.
  • David Bernal-Casas
    Independent Researcher, Barcelona, Spain.

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