AIMC Topic: Antibodies, Monoclonal, Humanized

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Interpretable attention-based deep learning ensemble for personalized ovarian cancer treatment without manual annotations.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society Apr 12, 2023
Inhibition of pathological angiogenesis has become one of the first FDA approved targeted therapies widely tested in anti-cancer treatment, i.e. VEGF-targeting monoclonal antibody bevacizumab, in combination with chemotherapy for frontline and mainte...
Humans Vascular Endothelial Growth Factor A Pyruvate Kinase Bevacizumab Angiopoietin-2 Female Deep Learning Antibodies, Monoclonal, Humanized Ovarian Neoplasms
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Prediction of vedolizumab treatment outcomes by machine learning.

Journal of biopharmaceutical statistics Jun 28, 2022
Machine Learning Treatment Outcome Antibodies, Monoclonal, Humanized Humans
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Relationship between vedolizumab serum concentrations in the induction phase and early and sustained response in the first year of treatment in patients with ulcerative colitis.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria Dec 22, 2021
OBJECTIVE: Evidence on the usefulness of proactive monitoring of vedolizumab serum concentrations during the induction phase of treatment is limited. The objective of our study was to evaluate the effectiveness of measuring such concentrations during...
Antibodies, Monoclonal, Humanized Humans Colitis, Ulcerative Prospective Studies Adult
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Deep Learning and the OPERA Trials for Multiple Sclerosis.

Radiology Dec 14, 2021
Antibodies, Monoclonal, Humanized Humans Multiple Sclerosis Deep Learning Multiple Sclerosis, Relapsing-Remitting
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Joint MRI T1 Unenhancing and Contrast-enhancing Multiple Sclerosis Lesion Segmentation with Deep Learning in OPERA Trials.

Radiology Dec 14, 2021
Background Deep learning-based segmentation could facilitate rapid and reproducible T1 lesion load assessments, which is crucial for disease management in multiple sclerosis (MS). T1 unenhancing and contrast-enhancing lesions in MS are those that enh...
Immunologic Factors Multiple Sclerosis Datasets as Topic Retrospective Studies Female Adult Male Deep Learning Antibodies, Monoclonal, Humanized Contrast Media Magnetic Resonance Imaging Humans
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Predicting response to immunotherapy plus chemotherapy in patients with esophageal squamous cell carcinoma using non-invasive Radiomic biomarkers.

BMC cancer Oct 30, 2021
OBJECTIVES: To develop and validate a radiomics model for evaluating treatment response to immune-checkpoint inhibitor plus chemotherapy (ICI + CT) in patients with advanced esophageal squamous cell carcinoma (ESCC).
Male Middle Aged Immune Checkpoint Inhibitors Nomograms Humans Tomography, X-Ray Computed Female Biomarkers, Tumor Bias Esophageal Neoplasms Combined Modality Therapy Carboplatin Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Antibodies, Monoclonal, Humanized Support Vector Machine Docetaxel Esophageal Squamous Cell Carcinoma
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Machine learning using clinical data at baseline predicts the efficacy of vedolizumab at week 22 in patients with ulcerative colitis.

Scientific reports Aug 12, 2021
Predicting the response of patients with ulcerative colitis (UC) to a biologic such as vedolizumab (VDZ) before administration is an unmet need for optimizing individual patient treatment. We hypothesized that the machine-learning approach with daily...
Male Middle Aged Adolescent Antibodies, Monoclonal, Humanized Colitis, Ulcerative Gastrointestinal Agents Remission Induction Proof of Concept Study Aged Aged, 80 and over Young Adult Adult Machine Learning Retrospective Studies Female Humans
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Central Reading of Ulcerative Colitis Clinical Trial Videos Using Neural Networks.

Gastroenterology Oct 21, 2020
BACKGROUND AND AIMS: Endoscopic disease activity scoring in ulcerative colitis (UC) is useful in clinical practice but done infrequently. It is required in clinical trials, where it is expensive and slow because human central readers are needed. A ma...
Colitis, Ulcerative Deep Learning Middle Aged Humans Adolescent Intestinal Mucosa Prospective Studies Colon Treatment Outcome Predictive Value of Tests Colonoscopy Female Antibodies, Monoclonal, Humanized Feasibility Studies Severity of Illness Index Aged Video Recording Young Adult Image Interpretation, Computer-Assisted Observer Variation Adult Male
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Biomarkers of the Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma.

Frontiers in immunology Aug 25, 2020
The mechanisms underlying the resistance to immune checkpoint inhibitors (ICIs) therapy in metastatic urothelial carcinoma (mUC) patients are not clear. It is of great significance to discern mUC patients who could benefit from ICI therapy in clinica...
Urothelium Urinary Bladder Neoplasms Predictive Value of Tests Carcinoma Drug Resistance, Neoplasm B7-H1 Antigen Nomograms Treatment Outcome Antibodies, Monoclonal, Humanized Machine Learning Gene Expression Profiling Decision Support Techniques Humans Transcriptome Risk Factors Clinical Decision-Making Time Factors Biomarkers, Tumor Female Immune Checkpoint Inhibitors Male Risk Assessment
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Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis.

Clinical therapeutics Dec 26, 2017
PURPOSE: Andecaliximab (GS-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (RA). This study assessed the safety and pharmacokinetic...
Matrix Metalloproteinase 9 Antirheumatic Agents Matrix Metalloproteinase Inhibitors Aged Antibodies, Monoclonal, Humanized Humans Antibodies, Monoclonal Male Female Infusions, Intravenous Middle Aged Double-Blind Method Arthritis, Rheumatoid
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