AI Medical Compendium

Deep learning-based CT model for non-invasive prediction of tertiary lymphoid structures in pancreatic cancer: a multicenter study with prospective validation in an immunochemotherapy cohort.

Journal for immunotherapy of cancer Sep 12, 2026

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Tertiary lymphoid structures (TLS) have emerged as key components of the tumor immune microenvironment, associated with improved survival and enhanced im... read more

Patient preferences for the use of AI in chest X-ray result processing and communication.

Radiography (London, England : 1995) Sep 12, 2026

INTRODUCTION: Artificial Intelligence (AI) tools are increasingly used in imaging such as X-rays, but there is limited evidence about how patients view the use of AI in the diagnostic process. METHODS: Using the Technology Acceptance Model (TAM) to s... read more

Overcoming cancer resistance in pancreatic cancer: toward dynamic precision oncology.

Molecular biology reports Sep 12, 2026

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy, largely because of its profound and evolving therapeutic resistance. Resistance is not determined by a single molecular alteration but arises from interconnected mechanisms, ... read more

Proteolysis Targeting Chimeras (PROTACs): Design and Mechanism.

Handbook of experimental pharmacology Sep 13, 2026

Proteolysis-targeting chimeras (PROTACs) are driving a fundamental shift in small-molecule drug discovery from the traditional "occupation-driven" to the innovative "event-driven" pharmacological paradigm. This chapter systematically reviews the deve... read more

Expanding the E3 Ligase Landscape: From Small Molecule to Biological Targeted Protein Degradation.

Handbook of experimental pharmacology Sep 13, 2026

Targeted protein degradation (TPD), particularly proteolysis-targeting chimeras (PROTACs), has emerged as a powerful strategy for eliminating disease-associated proteins through the ubiquitin-proteasome system. However, current PROTACs rely heavily o... read more

PRISM: Phase-Resolved Isotropic Subtraction Mapping for Automated Multi-Phase CT Digital Subtraction Angiography

medRxiv Sep 13, 2026

Multi-phase contrast-enhanced computed tomography (CT) is the gold standard for renal cell carcinoma (RCC) characterization, yet clinical interpretation relies on subjective visual comparison across phases. We present PRISM (Phase-Resolved Isotropic ... read more

radiology and imaging

Integrating structured and unstructured EHR data to characterize social and behavioral factors associated with frequent emergency department use among patients with cardiovascular disease

medRxiv Sep 12, 2026

Objective: The goal was to integrate structured and unstructured data from the electronic health record (EHR) to identify social and behavioral determinants of health (SBDH) factors and evaluate their association with high emergency department (ED) u... read more

emergency medicine

Human Myopia: Past, Present and Future.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) Sep 12, 2026

The study of human myopia spans over two millennia, yet many of the principles shaping current research and management trace their origins to the scientific advances of the late nineteenth century. This review takes a broad historical perspective on ... read more

Machine learning integrated explainable artificial intelligence in predicting toxicities of enfortumab vedotin in urothelial carcinoma: an exploratory study.

Expert review of anticancer therapy Sep 12, 2026

BACKGROUND: Enfortumab vedotin (EV) therapy for advanced urothelial carcinoma is limited by adverse events (AEs). Early identification of high-risk patients is needed. This proof-of-concept study evaluated whether machine learning (ML) with explainab... read more

The role of artificial intelligence in the diagnosis and prognosis of traumatic brain injury based on brain CT scans: a systematic review.

Neurosurgical review Sep 12, 2026

Traumatic brain injury (TBI) is a leading cause of emergency department visits and a major contributor to injury-related mortality and long-term neurological disability. Non-contrast computed tomography (CT) is the gold-standard imaging modality for ... read more

Artificial Intelligence Medical Compendium