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Computer Simulation

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Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of 'redu...

A classification-occupancy model based on automatically identified species data.

Ecology
Occupancy models estimate a species' occupancy probability while accounting for imperfect detection, but often overlook the issue of false-positive detections. This problem of false positives has gained attention recently with the rapid advancement o...

Assessing subvisible particle risks in monoclonal antibodies: insights from quartz crystal microbalance with dissipation, machine learning, and in silico analysis.

mAbs
Throughout the lifecycle of biopharmaceutical development and manufacturing, monoclonal antibodies (mAbs) are subjected to diverse interfacial stresses and encounter various container surfaces. These interactions can cause the formation of subvisible...

Machine learning assisted in Silico discovery and optimization of small molecule inhibitors targeting the Nipah virus glycoprotein.

Scientific reports
The Nipah virus (NiV), a lethal pathogen from the Paramyxoviridae family, presents a significant global health threat as a result of its high mortality rate and inter-human transmission. This investigation employed in silico methods that were assiste...

A controller of robot constant force grinding based on proximal policy optimization algorithm.

PloS one
In order to solve the problems of high dependence on the accuracy of environmental model and poor environmental adaptability of traditional control methods, the robot constant force grinding controller that based on proximal policy optimization was p...

Exploring the evolutionary adaptations of the unique seahorse tail's muscle architecture through modelling and robotic prototyping.

Journal of the Royal Society, Interface
Seahorses possess a unique tail muscle architecture that enables efficient grasping and anchoring onto objects. This prehensile ability is crucial for their survival, as it allows them to resist currents, cling to mates during reproduction and remain...

AI-Assisted Hypothesis Generation to Address Challenges in Cardiotoxicity Research: Simulation Study Using ChatGPT With GPT-4o.

Journal of medical Internet research
BACKGROUND: Cardiotoxicity is a major concern in heart disease research because it can lead to severe cardiac damage, including heart failure and arrhythmias.

LLM-based robot personality simulation and cognitive system.

Scientific reports
The inherence of personality in human-robot interaction enhances conversational dynamics and user experience. The deployment of Chat GPT-4 within a cognitive robot framework is designed by using state-space realization to emulate specific personality...

RRT-CS: A free-collision planner for capsule-like SCORBOT by iterated learning.

PloS one
In this study, we present an enhanced Rapidly-exploring Random Trees (RRT) algorithm integrated with a visual servoing technique for recognizing unknown environments. The robotic platform utilized is the SCORBOT-ER-VII, which consists of five links, ...

Inverse modeling, analysis and control of twin rotor aerodynamic systems with optimized artificial intelligent controllers.

PloS one
This paper suggests a novel optimal inverse Radial Basis Function (RBF) neural network model for the control of Twin Rotor Aerodynamic Systems (TRAS), such as Multi-Input-Multi-Output (MIMO) systems with high nonlinearity and coupling effects between...