Cancer stem cells (CSCs) drive tumour initiation, progression, metastasis, and therapy resistance through their remarkable plasticity, enabling dynamic transitions between stem-like and differentiated states. A pivotal mechanism underlying this plast... read more
BMC medical informatics and decision making
May 25, 2026
BACKGROUND AND OBJECTIVE: Interpretation of urodynamic studies (UDS) is essential for the assessment of lower urinary tract dysfunction but remains resource-intensive and highly operator-dependent. Artificial intelligence (AI) has increasingly been a... read more
The COVID-19 pandemic showed that heterogeneous antiviral assay designs, endpoints and reporting practices can obscure which candidate drugs and combinations are genuinely promising. As antiviral discovery expands from acute infections to chronic and... read more
BACKGROUND: Endometriosis is a heterogeneous gynecological disorder characterized by chronic pain, infertility, and substantial impairment of quality of life. Increasing evidence indicates that microRNAs (miRNAs) are key regulators of endometriosis p... read more
PURPOSE: Radiotherapy treatment planning is currently premised on individual clinical experience and use of many dose based optimization and knowledge-based planning (KBP) models. This study introduces and validates a novel KBP algorithm that matches... read more
Accurate prediction of fire consequences is fundamental to process safety management and quantitative risk assessment in the chemical process industries. Traditional empirical and computational fluid dynamics models often struggle to balance computat... read more
OBJECTIVES: To evaluate the construct validity of a commercially available multimodal foundation model (Google Gemini 2.5 Pro) in assessing simulated injection laryngoplasty. METHODS: Thirty video recordings of simulated injection laryngoplasty proce... read more
BACKGROUND: Accurate preoperative staging in colorectal cancer (CRC) is critical for determining the appropriate treatment strategy. This study evaluated whether early-stage (TNM I-II) and advanced-stage (TNM III-IV) CRC could be distinguished using ... read more
BACKGROUND: Advancements in artificial intelligence have led to the widespread use of large language models such as ChatGPT in healthcare communication. Myotonic dystrophy type 1, a chronic and multisystemic neuromuscular disorder, poses significant ... read more
PURPOSE: 18 F-FDG PET/CT is the standard modality for monitoring treatment response in metastatic breast cancer. This study aims to evaluate the predictive value of delta-radiomics derived solely from the low-dose, non-contrast CT component acquired ... read more
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