Objective This study aimed to train and evaluate supervised machine learning algorithms using electronic health record (EHR) data to accurately estimate gestational age at delivery. Materials and Methods We trained random forest, gradient boostin... read more
Background: Accurate extraction of Human Phenotype Ontology (HPO) terms from clinical notes is essential for variant prioritization and genetic diagnosis. Large language models (LLMs) often struggle to balance precision, hallucination avoidance, and ... read more
While the expansion of spatial omics has revolutionized our ability to dissect tissue architecture, the accumulation of incompatible computational methods has heavily fragmented end-to-end analysis, rendering complex workflows irreproducible. Generic... read more
Genomic foundation models have emerged alongside the rapid progress of large language models, offering a promising framework for learning general-purpose sequence priors for DNA understanding, generation, and design. This connection to LLMs creates a... read more
Surface-enhanced Raman scattering (SERS) nanotags provide highly sensitive platforms for in vitro diagnostics but often require complex, disease-specific customization that limits clinical translation. Biomineralization, in which biomolecules mediate... read more
Background Influenza A virus (IAV) is a major public health burden, causing seasonal epidemics and occasional pandemics. Its transmission from avian species to mammals and subsequent spread requires adaptive changes in the viral genome. Understanding... read more
Tissue-specific chromatin states shape regional mutation density in primary tumors, but whether this relationship persists in metastases is unclear. We integrated whole-genome sequencing data from 2,507 metastatic tumors across six cancer types with ... read more
Tuberculosis remains a leading cause of infectious disease mortality, and the continued emergence of drug-resistant Mycobacterium tuberculosis strains threatens the effectiveness of standard treatment regimens. Culture-based antibiotic susceptibility... read more
Reliable early warning of infectious disease outbreaks remains a major challenge for surveillance systems, particularly for vector-borne pathogens whose transmission depends on interactions among hosts, vectors, and climate-sensitive environmental co... read more
Horizontal gene transfer (HGT), the movement of genetic material between unrelated organisms, is widely recognized as an important driver of genome evolution in bacteria. In eukaryotes, however, the evolutionary impact of HGT remains debated. The ide... read more
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