BACKGROUND: Vesicoureteral reflux (VUR) is a common urological disorder in children. To date, VUR severity is assessed by grading, and contemporary models have expanded on developing predictors for breakthrough UTI (bUTI) in VUR. Here, we developed m... read more
INTRODUCTION: Accurate assessment of stone burden is fundamental in urolithiasis, as it directly influences treatment selection and prognostic evaluation. Although maximum stone diameter on non-contrast computed tomography remains the most widely use... read more
Accurately assessing how individual cells respond to anticancer agents remains challenging because most assays provide bulk or binary readouts and cannot translate single-cell imaging into scalable, mechanism-relevant quantification. Here, we develop... read more
Journal of biopharmaceutical statistics
May 24, 2026
Pharmaceutical polymorphism and crystallinity changes may have significant impact on drug's quality, efficacy, and safety. The risk mitigation strategies include pharmaceutical development, monitoring and control strategy establishment during manufac... read more
Reliable early warning of infectious disease outbreaks remains a major challenge for surveillance systems, particularly for vector-borne pathogens whose transmission depends on interactions among hosts, vectors, and climate-sensitive environmental co... read more
Human-associated microbial genomes encode extensive strain-level diversity and niche-specific gene repertoires that are critical to host health. However, these complex sequence features remain difficult to capture using general-purpose DNA foundation... read more
Horizontal gene transfer (HGT), the movement of genetic material between unrelated organisms, is widely recognized as an important driver of genome evolution in bacteria. In eukaryotes, however, the evolutionary impact of HGT remains debated. The ide... read more
While single neuron responses in mouse V1 are well characterized, less is known about how functional ensembles--groups of neurons that co-activate more frequently than expected by chance--emerge as computational units within laminar V1 circuits. Even... read more
Pressure injuries represent a significant healthcare challenge requiring early detection to prevent severe complications. While thermal imaging shows promise for detecting early pressure-related temperature changes, its robustness across varying imag... read more
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