Lipid metabolism is abnormal in patients with atopic dermatitis (AD). This study aimed to screen lipid metabolism-related gene (LMRG) in AD, providing insights into the underlying mechanisms of lipid metabolism abnormalities in AD. Gene expression pr... read more
AbstractPulmonary infections caused by nontuberculous mycobacteria (NTM), particularly Mycobacterium avium complex (MAC), are increasingly recognized as an important clinical entity, yet distinguishing active pulmonary disease from asymptomatic colon... read more
Machine learning (ML) models with stochastic and non-deterministic characteristics are increasingly used for genomic prediction in plant breeding, but evaluation often neglects important aspects like prediction stability and ranking performance. This... read more
We present vL27, a benchmark data set of 27 large noncovalent complexes with sizes up to 205 atoms, designed to probe nanoscale interaction effects. Reference binding energies were computed using local coupled cluster with single, double, and perturb... read more
Hydroxymethanesulfonate (HMS), formed from liquid-phase reactions of formaldehyde (HCHO) and SO2, is a key organosulfur component. While its importance in northern China's sulfur chemistry is recognized, HMS dynamics in southern coastal regions remai... read more
The journal of physical chemistry letters
May 23, 2026
Natural antifreeze proteins (AFPs) demonstrate exquisite structure-function relationships, while in silico designs often struggle to achieve a balance among structural stability, expression efficiency, and functional activity. This study establishes ... read more
Alternatives to animal models, including computational-based approaches, are now prioritized by regulatory and funding agencies in biomedical research. Despite this shift in policy, computer models in tissue engineering and regenerative medicine rema... read more
Efficient drug delivery remains a major challenge in pharmaceutical science, with synthetic nanocarriers often facing limitations in real biological systems. While blood platelets have been explored as biomimetic carriers, their intrinsic capacity fo... read more
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