Hospital antimicrobial resistance (AMR) emanates from an array of complex interactions between patient turnover, heterogeneous patient--staff contact patterns, antibiotic-driven within-host selection, and imperfect surveillance. We present a hospital... read more
Clinical AI systems have achieved strong predictive performance; however, prediction accuracy is not sufficient for clinical safety. Retrieval-augmented generation (RAG) improves factual accuracy, and general-purpose LLM guardrails constrain surface-... read more
The liver plays a central role in systemic metabolism, yet large-scale genetic studies of quantitative liver imaging phenotypes remain limited. Here, we applied deep learning-based segmentation and radiomics extraction to derive 200 well-defined live... read more
Background: Professionalism and effective communication are foundational determinants of patient safety and quality of care. Unprofessional behaviors frequently serve as active precursors to adverse clinical events. However, proactive organizational ... read more
Background Background breast features are frequently noted in pathology reports alongside invasive breast cancer but rarely factor into prognosis or treatment decisions. Their relationship to tumor characteristics and patient outcomes remains incompl... read more
Background: Machine-learning models based on circulating biomarkers are increasingly used in cardiovascular research; however, model performance alone provides limited insight into how the predictive signal is distributed across features. We aimed to... read more
Background Community-wide active case-finding (ACF) is being increasingly implemented as a tuberculosis (TB) elimination intervention. However, conventional site selection strategies may result in low yields from screening. We evaluated whether an ar... read more
Purpose: Psychological distress is highly prevalent in glaucoma and is associated with worse adherence, reduced quality of life, and faster disease progression. However, distress is rarely assessed in ophthalmology settings due to time, workflow, and... read more
Research applications of electronic health record (EHR) phenotypes require translating clinical definitions into executable EHR database queries, a labor-intensive process. We evaluated two frontier large language models across five phenotypes and th... read more
Adolescence is a critical developmental window for the emergence of substance use and psychosis-spectrum symptoms, yet early risk for these outcomes remains poorly understood. Using longitudinal data from the Adolescent Brain Cognitive Development (A... read more
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