Background: African Americans (AA) experience disproportionate burden of colorectal cancer (CRC). Dysregulation of the Wingless-related integration site (WNT) pathways contributes to tumor progression, yet their prognostic roles in FOLFOX-treated CRC... read more
Background: Parkinson's disease (PD) has a prolonged prodromal phase during which non-motor symptoms (NMS) may emerge years before the appearance of classical motor signs. This makes NMS a promising and clinically accessible source of information for... read more
Importance: Abdominal pain causes roughly 10 million US emergency department (ED) visits annually, most resulting in discharge. Post-discharge courses vary, yet existing risk models predict only whether an ED revisit occurs, not what that revisit out... read more
Objectives: AI-based reconstructions can reduce MRI acquisition times and/or improve image quality. Guidelines recommend clinical evaluations and post-deployment monitoring of these novel methods, however, there has been little investigation of the c... read more
Physical activity (PA) plays an important role in maintaining and improving health. Daily steps have been a key PA measure that is easily accessible with common wearable devices. However, methods are lacking to recommend a personalized optimal distri... read more
Background: Heart failure (HF) is a major contributor to inpatient hospital utilization, with persistently high 30-day readmission rates. Existing prediction tools are frequently restricted to primary-diagnosis HF admissions, potentially excluding cl... read more
Background: Structuring oncology clinical notes into registry-grade variables is essential for research and care but remains labour-intensive and error-prone. Objective: To develop and evaluate a privacy-preserving large language model pipeline for o... read more
Background: Alzheimers disease (AD) is a multifactorial neurodegenerative disorder in which copper dyshomeostasis, mitochondrial stress, oxidative injury and immune dysregulation may contribute to pathogenesis. Cuproptosis, a copper-triggered regulat... read more
Background Patients worldwide receive healthcare in many languages, yet medical AI systems are validated almost exclusively in high-resource languages such as English and Chinese, exposing patients in other linguistic settings to unquantified diagnos... read more
Accurate gene prediction remains a major bottleneck in fungal genomics, where lineage diversity and alternative splicing challenge existing ab initio methods. Here, we present geneML, a deep learning-based gene prediction tool tailored to fungal geno... read more
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