Artificial Intelligence Medical Compendium

Machine learning has become an increasingly powerful tool in enzyme discovery, enabling the prediction of enzyme activity, substrate scope, and functional specificity across diverse protein families. However, many reported models rely on narrowly sam... read more 

Determining traffic crash liability relies on rigorous on-site evidence and legal provisions and involves substantial manual intervention and potential human error. However, intelligent traffic monitoring systems focus on detection and tracking and c... read more 

BACKGROUND: In-laboratory attended Polysomnography (PSG) is the reference standard for objective sleep assessment. Although portable and wearable sleep technologies have advanced, the evolution of PSG research over the past decade has not been system... read more 

Fipronil and its metabolites (FPM) are widely detected in environmental and biological matrices, but human evidence of developmental hepatotoxicity remains scarce. We quantified six fipronil-related compounds, five liver-function biomarkers, and four... read more 

Perturbation of microbial-derived bile acid (BA) metabolism is strongly linked to the pathogenesis of intestinal diseases, including inflammatory bowel disease, enteric infections, and colorectal cancer. Recent advances in artificial intelligence-ass... read more 

Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequence-to-function deep learning models to systematically... read more 

Biological neural networks contain diverse cell types with heterogeneous electrophysiological properties. Artificial neural networks (ANNs) model computational aspects of biology but use homogeneous neurons, limiting realism. A key obstacle to buildi... read more 

Chimeric antigen receptor (CAR) T cell therapy has transformed treatment of resistant cancers, yet it faces major limitations such as variable patient responses, relapse, and safety issues. Optimizing CAR T cell treatment regimens and genetic design ... read more 

The 39th International Conference on Antiviral Research (ICAR), hosted by the International Society for Antiviral Research (ISAR), took place April 27-May 1, 2026, at the Cubex Centrum Praha in Prague, Czech Republic. The annual meeting brought toget... read more 

Patients with resected pancreatic ductal adenocarcinoma (PDAC) can have different outcomes despite similar TNM stage. We developed TIGERS (Tumor Intelligence Grading and Evaluation Risk Score), a nine-feature prognostic biomarker derived from routine... read more