Background: Alzheimers disease (AD) is a multifactorial neurodegenerative disorder in which copper dyshomeostasis, mitochondrial stress, oxidative injury and immune dysregulation may contribute to pathogenesis. Cuproptosis, a copper-triggered regulat... read more
Single-cell RNA sequencing (scRNA-seq) provides unprecedented resolution of cellular heterogeneity while also capturing information on germline genetic variation, but accurate variant calling remains limited by sparse coverage, allelic imbalance, and... read more
Ensuring global food security under rapid climate change demands accelerated genetic gain and breeding strategies that address complex Genotype-by-Environment (GxE) interactions. Traditional genomic selection models often fail to account for novel or... read more
Presurgical mapping of key white matter (WM) fiber tracts is crucial for intracerebral hemorrhage (ICH) surgery, but it currently relies on tractography from diffusion MRI (dMRI), which has limited applicability in urgent or resource-constrained sett... read more
Accurate gene prediction remains a major bottleneck in fungal genomics, where lineage diversity and alternative splicing challenge existing ab initio methods. Here, we present geneML, a deep learning-based gene prediction tool tailored to fungal geno... read more
stimulation (tTIS) is a promising non-invasive brain stimulation technique that has the potential to selectively modulate deep brain regions by delivering two high-frequency alternating currents that interfere to produce a low-frequency amplitude-mod... read more
Identifying what makes species vulnerable to extinction requires accounting for complex biological and environmental interactions. Due to their high predictive accuracy, machine learning methods have been widely used for these assessments; however, r... read more
Deep learning-based structure prediction enables the design of peptide ligands without relying on naturally occurring scaffolds. However, most computationally generated peptides are not advanced beyond initial activity measurements, leaving the path ... read more
Though currently a minor crop, faba bean is a promising source of plant-based protein as global diets shift towards more plant-based nutrition. To realise this potential, advances in breeding and cultivation are crucial. To exploit heterosis, faba be... read more
Motivation: Tabular-to-image methods allow convolutional neural network (CNN)-based classifiers to analyse high-dimensional biological tables by mapping features onto a two-dimensional grid. Existing layouts are usually driven by unsupervised global ... read more
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