AI Medical Compendium

Decoding the role of polyamine metabolism in lung adenocarcinoma prognosis: A triangulated approach combining transcriptome, single-cell and Mendelian randomization analyses.

Oncology letters May 21, 2026

The progression of lung adenocarcinoma (LUAD) is influenced by polyamine metabolism, which modulates antitumor immunity, although the underlying mechanisms remain unclear. The present study investigates the role of polyamine metabolism-related genes ... read more

An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2.

Brain, behavior, & immunity - health May 20, 2026

Many individuals hospitalized due to severe viral infections develop mental and physical sequelae, which could potentially be prevented by targeted interventions for those at risk. Our goal was to develop and externally validate an algorithm for pred... read more

A machine learning-based workflow for transaminase selection.

Chemical science May 20, 2026

Transaminases can be strategically used in medicinal chemistry for the synthesis of chiral amine building blocks in a straightforward manner that alleviates the need for chiral preparative separations. However, selection of the commercial transaminas... read more

Linking molecular heterogeneity of artificial humic acid to divergent cadmium coordination behaviors.

Journal of hazardous materials May 20, 2026

Humic substances strongly influence the environmental behavior of toxic metals, but the molecular basis by which compositionally similar humic systems promote either metal immobilization or activation remains unclear. To resolve this, cadmium (Cd) wa... read more

Cooperative membrane association as a mechanistic origin of synergistic antimicrobial peptide activity.

RSC chemical biology May 20, 2026

Antimicrobial peptides (AMPs) are central components of the innate immunity system that can be found in almost all living organisms. They are promising alternatives to conventional antibiotics due to their broad-spectrum activity and reduced suscepti... read more

LRF-CNN: An explainable lightweight receptive field-based CNN for colorectal cancer histopathological image classification.

iScience May 20, 2026

Colorectal cancer (CRC) screening and diagnosis rely on histopathological assessment, but many high-performing deep learning (DL) models remain computationally demanding and difficult to interpret. This study presents an explainable lightweight recep... read more

Integrated metabolic and inflammatory biomarkers for early association and prediction of adverse pregnancy outcomes: a multicenter validation study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians May 20, 2026

BACKGROUND: Adverse pregnancy outcomes (APOs) affect long-term maternal and offspring health. Conventional metabolic markers, including the triglyceride-glucose (TyG) index, inadequately capture pregnancy-related immuno-inflammatory dysregulation. We... read more

Data fusion in air pollution exposure assessment: Methods, applications, and future directions.

Journal of the Air & Waste Management Association (1995) May 20, 2026

Over the past two decades, major advances in observational techniques and modeling capabilities have enabled the development of air pollution data fusion methods that integrate information from regulatory monitoring networks, low-cost sensors, satell... read more

Attention-Based Point Cloud Completion for CT-Equivalent Kidney Volumetry from Tracked Freehand Ultrasound.

Journal of imaging informatics in medicine May 20, 2026

Kidney volume measurement is critical for managing polycystic kidney disease and monitoring transplants, but computed tomography involves radiation and conventional ultrasound has 20-30% error. This study validates tracked freehand ultrasound with at... read more

Comment on "Digital Twins and Multimodal Artificial Intelligence in Spine Care: A Scoping Review of Concepts, Evidence, and Translational Barriers".

Spine deformity May 20, 2026

Artificial Intelligence Medical Compendium