AI Medical Compendium

Emerging Trends and Future Directions in CO-AMORPHOUS Solid Dispersions for BCS Class II and IV Drugs.

Drug development and industrial pharmacy May 20, 2026

OBJECTIVE: The objective of this review is to critically evaluate the potential of co-amorphous solid dispersions (CASDs) in improving the performance of poorly soluble active pharmaceutical ingredients (APIs). SIGNIFICANCE: CASDs are being scoped in... read more

Computational models for the classification of antibody specificity using heavy chain features.

PloS one May 20, 2026

BACKGROUND: Antibodies play a critical role in immune defense, with their antigen specificity primarily governed by the unique sequences of their heavy chains, rendering them invaluable tools in research and diagnostics. High-throughput sequencing te... read more

Quality of Responses Generated by Artificial Intelligence Chatbots for Frequently Asked Questions by Caregivers of Presurgical Nasoalveolar Molding Therapy.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association May 20, 2026

ObjectiveThe study compared the quality of responses generated by three artificial intelligence chatbots (AICs) for frequently asked questions (FAQs) by caregivers of presurgical nasoalveolar molding (PNAM) therapy.Material and MethodsTwenty-three FA... read more

Brain morphology in Anorexia Nervosa and its subtypes: A multi-cohort study of individual participant data.

PLoS medicine May 20, 2026

BACKGROUND: In a recent coordinated meta-analysis of neuroimaging data, we reported gray matter (GM) alterations in acutely underweight patients with anorexia nervosa (AN). Here, we extend these findings by examining individual variation in brain str... read more

De Novo Design of Miniature and Efficient Metallo-Ketoreductases.

Journal of the American Chemical Society May 20, 2026

The rational design of enzymes capable of catalyzing abiotic transformations represents a frontier in synthetic biocatalysis. While computational strategies have successfully produced enzymes for acid-base chemistry, examples of de novo designed oxid... read more

TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.

Proceedings of the National Academy of Sciences of the United States of America May 20, 2026

Fibroblasts are key potentiators of chronic disease pathophysiology. Despite their established roles in promoting pathological inflammation and tissue remodeling, activated myofibroblasts are generally characterized as a single, homogeneous cell popu... read more

Multimodal data integration to determine viral and innate immune kinetics in human airway epithelium.

PLoS computational biology May 20, 2026

Understanding the mechanisms that govern viral spread in human airway epithelium (HAE) remains a major challenge, particularly with regard to identifying and quantifying key factors such as cell-type-specific infectivity, viral transmission paths, an... read more

Shared diagnostic biomarkers in metabolic syndrome and coronary artery disease identified by integrated bioinformatics and machine learning.

Endocrine connections May 20, 2026

BACKGROUND: Metabolic syndrome (MetS) comprises various complicated metabolic disorders. Coronary artery disease (CAD) is a major cardiovascular disease worldwide. These two diseases are principal causes of morbidity and mortality in old adults. Prev... read more

Bioinspired ionic thermoreceptors with anisotropic architecture for thermotactile perception in robots.

Science advances May 20, 2026

Emulating human skin's ability to perceive temperature and identify material through thermotactile perception is critical for human-machine interaction, robotics operation, and prosthetic sensory feedback systems. However, conventional artificial the... read more

Tropical basin interactions reduce spring predictability barrier of ENSO in a deep learning model.