Background: Anemia is an established marker of cardiovascular disease severity and risk which leads to elevations in resting myocardial blood flow (MBF) and impaired myocardial flow reserve (MFR) in patients without obstructive coronary artery diseas... read more
Distant melanoma metastasis at the time of diagnosis is uncommon, but has major implications for patient prognosis and treatment selection. However, few tools can reliably predict the risk of distant metastasis at initial presentation. Here, we devel... read more
Delayed diagnosis and poor antiretroviral therapy (ART) adherence remain primary drivers of HIV-related morbidity in low-resource settings, yet real-world AI validation at scale is lacking. We conducted a retrospective validation study using two publ... read more
Objective: Readmissions to the PICU are associated with increased morbidity and mortality. A prediction model that can identify children at risk of readmission at the time of transfer can allow providers to intervene and potentially improve patient o... read more
Background Increasingly accessible satellite imagery provides scalable measures of the built and natural environment relevant to population health. However, whether such imagery can capture subnational variation in mortality and life expectancy remai... read more
STATEMENT OF PROBLEM: Despite the increased use of direct-to-abutment connections for implant-supported fixed complete dental prostheses (ISFCDPs), limited evidence exists regarding marginal adaptation and internal fit, 2 parameters critical for biom... read more
Synonymous mutations, long regarded as evolutionarily neutral, are increasingly recognized as important determinants of viral evolution and adaptation. In this review, we propose that viral codon usage reflects a multi-objective optimization process ... read more
RATIONALE AND OBJECTIVES: To evaluate whether intratumoral habitats and peritumoral regions on ultrasound (US) images enhance radiomics-based diagnosis of calcified breast lesions. MATERIALS AND METHODS: Mammography-confirmed calcified breast lesions... read more
MRI is the most effective method for screening high-risk breast cancer patients. While current exams rely on the qualitative evaluation of morphological features before and after contrast administration and less on contrast kinetic information, recen... read more
Respiratory disease outbreaks burden American healthcare systems with over one million hospitalizations annually, yet current surveillance systems lag 1-2 weeks behind real-time conditions, preventing timely intervention. We present a machine learnin... read more
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