Agentic tools - software environments where a large language model plans, calls external tools, executes code, and iterates with minimal human intervention - will run a substantial share of routine biomedical data analysis within the next few years. ... read more
Purpose: In clinical practice, accurate prediction of disease risk must be accompanied by transparent, human-understandable explanations to support diagnostic confidence, guide therapeutic decisions, and meet ethical and regulatory standards. While d... read more
Quantitative pupillometry provides a noninvasive window into brain state and neurological function, but its broader use across experimental and clinical settings is limited by challenges in achieving accurate, scalable, and generalizable measurements... read more
While tree pollen is a major trigger of allergic respiratory conditions and different taxa exhibit varying allergenic potentials, the lack of high-resolution, taxon-specific exposure metrics have limited our ability to identify which local pollen tax... read more
Drug-target affinity (DTA) prediction is a key task in drug discovery, enabling the estimation of the interaction strength between candidate compounds and biological targets. However, current models rely on connectivity-based molecular representation... read more
Ab initio prediction of side effect frequencies is important for assessing the risk-benefit profile of drugs and for identifying potential adverse effects early in development. A key challenge is chirality: many drugs exist as enantiomers, pairs of m... read more
Lung adenocarcinoma (LUAD), a subtype of non-small cell lung cancer (NSCLC), is the most common primary lung cancer worldwide. Despite advancements in early detection and treatment, up to 39% of patients develop recurrent tumors following complete re... read more
Background: DNA lesions arise from endogenous metabolism and environmental exposure and are the major drivers of mutagenesis, aging, and cancer development. However, mapping DNA damage at nucleotide resolution remains a technically challenging task. ... read more
Selective deployment of multiple transcription start sites is a major regulatory feature of human transcriptomes. FANTOM CAGE data exhibit a near-universal TSS deployment parsimony which is disrupted in cancers. We have recently shown that TSS deploy... read more
Intrinsically disordered proteins (IDPs) drive a large fraction of cellular signaling, transcription and assembly through interfaces that lack a single defined geometry, making the prediction of their binding energies beyond the reach of methods cali... read more
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