BACKGROUND: Pediatric heart failure (PHF) carries a high mortality burden, yet the prognostic value of admission blood pressure (BP) remains poorly defined, and evidence-based thresholds for risk stratification are lacking. METHODS: This retrospectiv... read more
UNLABELLED: Immunization is one of the most effective interventions to prevent infectious diseases. Identifying individuals at risk of non-adherence to immunization schedules could enable early interventions to improve coverage. With the increasing a... read more
INTRODUCTION: The multidisciplinary heart team (HT) remains the cornerstone of decision-making for complex cardiovascular disease. Large language models (LLMs) and other generative artificial intelligence models have recently emerged as potential dec... read more
OBJECTIVES: To develop and validate interpretable machine learning (ML) models incorporating MRI-derived paraspinal muscle parameters to predict new vertebral compression fractures (NVCF) after vertebral augmentation. MATERIALS AND METHODS: This mult... read more
Although many predictive models for metabolic dysfunction-associated steatotic liver disease (MASLD) have been developed, their performance remains suboptimal. We aimed to develop an interpretable machine learning (ML)-based plasma biomarker model fo... read more
Whole-slide histopathological images (WSIs) constitute a fundamental approach in disease diagnosis and prognosis. Recently emerging spatial transcriptomics (ST) methods can reveal the spatial gene expression landscape behind the histopathological ima... read more
OBJECTIVES: Depth of stromal invasion (DSI) is a key prognostic factor significantly influencing treatment decisions in early-stage cervical cancer (ESCC). This study aims to develop an explainable multimodal data fusion model integrating MRI, radiol... read more
INTRODUCTION: Nemolizumab is a humanized monoclonal antibody that specifically inhibits the receptor for interleukin-31, the major pruritogen in atopic dermatitis (AD). While the patient profile associated with the early therapeutic response to nemol... read more
Omics : a journal of integrative biology
May 15, 2026
Metabolomics is the comprehensive analysis of small-molecule metabolites in living systems and is increasingly being applied in forensic science and health diagnostics. This review broadly integrates the foundational principles of metabolomics, key a... read more
BACKGROUND: Coal-dust, a persistent airborne pollutant, induces dose-related pulmonary fibrosis; however, plasma biomarkers for pre-clinical toxicity remain lacking. METHODS: We enrolled 158 participants, including 28 healthy controls (HCs), 30 dust-... read more
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