Biological organisms are driven by thermodynamic self-preservation, whereas large language models operate as dissipative tools decoupled from existential constraints. We introduce a metabolic model translating this imperative of life into a computati... read more
Aptamers are single stranded DNA or RNA molecules selected for their high affinity and specificity to bind target molecules, similar to antibodies. They are commonly selected through the SELEX process, which involves the iterative exposure of a rando... read more
Copy number variations (CNVs) are major structural genomic variants that contribute to a wide range of human diseases. Accurate detection of CNVs from whole-exome sequencing (WES) data has been a long-sought goal for clinical and population genetic s... read more
Conformational plasticity of RNAs plays important roles in recognizing RNA-binding proteins, and is often modulated by their binding partners. Here, we investigate RNA conformational preferences in a non-redundant dataset of 263 protein-RNA complexes... read more
Humans comprehend language incrementally, updating the representation of sentence meaning with each incoming word. These updates are guided by the distance between each perceived word and prior expectations--the prediction error. The alignment betwee... read more
The mutation accumulation (MA) hypothesis posits that somatic mutations progressively escape selection and degrade tissue function during aging. Direct tests of this idea have been limited by the difficulty of predicting, at scale, the molecular cons... read more
Artificial intelligence holds the potential to expand the frontier of scientific research, yet recent work has raised concern that it may instead narrow scientific attention to well-established areas. Here, leveraging the 2021 release of AlphaFold2 a... read more
Brain similarity networks (BSNs), extracted from structural magnetic resonance imaging, provide a validated framework for studying brain network organization and encode neurodevelopmental information relevant for psychiatric disorders. Recently, a ne... read more
Background: Meningiomas are the most common primary intracranial tumors in adults, and volumetric assessment increasingly guides surveillance and treatment decisions. Automated segmentation could enable standardized volumetry but requires robust vali... read more
Rheumatic heart disease (RHD) remains a major public health concern across low- and middle-income countries in the Global South. Early detection through community-based screening of asymptomatic individuals has been identified as a critical strategy ... read more
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