Characterizing the fine-grained functional organization of human higher visual cortex remains a central challenge, as traditional neuroimaging experiments constrain the diversity of stimuli that can be sampled. In prior work we addressed this challen... read more
Recent advances in language models for natural language processing have spread to the field of genomics, driving the development of genome language models (gLMs) to decipher genomic information. Cutting-edge long-context gLMs are promising approaches... read more
Behavior arises from the complex interplay between the nervous system, genetics, and the environment. High-resolution, high-throughput behavioral quantification is essential for dissecting biological function and the effects of genetic perturbation, ... read more
Parameter estimation in nonlinear biological dynamical systems is a difficult inverse problem because the governing equations are often stiff or oscillatory, the data are sparse and noisy, and the objective landscape is non-convex. Physics-informed n... read more
Machine-learning surrogate models are positioned to help optimize deep brain stimulation (DBS) usage by predicting neural activation in response to electrical stimulation, while minimizing tradeoffs between computational expense and accuracy. Previou... read more
Developing scientific hypotheses in biology requires integrating heterogeneous evidence across DNA sequence, gene context, protein function, and prior literature. Existing multimodal AI systems expose biological evidence to reasoning models through t... read more
Artificial intelligence has reached a pivotal threshold. Multimodal large models can approach human-level speech comprehension by rapidly transforming sound into meaning. However, whether this process relies on human-like mechanisms remains unknown. ... read more
Recent deep learning models for L1000 chemical perturbation prediction incorporate dedicated drug molecular encoders. We retrained seven such models from scratch with zeroed or shuffled drug inputs, and compared them with a multilayer perceptron that... read more
Sequence-to-Function (S2F) foundation models are revolutionizing genomic research, yet their fragmented ecosystem severely bottlenecks practical application by incompatible inputs, outputs, and runtime environments. General-purpose coding agents lack... read more
Glioblastoma multiforme (GBM) is characterised by profound genomic heterogeneity and heavy-tailed gene-expression distributions that challenge conventional machine-learning methods. We introduce the Tsallis-Gated Autoencoder (Tsallis-GAE), a physics-... read more
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