AI Medical Compendium

TOPOS: target organ prediction on scout views for automated CT scan planning.

European radiology May 14, 2026

BACKGROUND: Overscanning is a common issue in CT planning, leading to unnecessary radiation exposure. PURPOSE: To develop a deep learning model to segment anatomical structures in scout views to optimize scan ranges and reduce radiation. MATERIALS AN... read more

Identification of key genes related to macrophages and metabolic reprogramming in myocardial infarct based on single-cell and bulk transcriptomics data and experimental validation.

BMC cardiovascular disorders May 14, 2026

BACKGROUND: Myocardial infarction (MI), one of the most severe cardiovascular diseases, is influenced by altered macrophage status and metabolic reprogramming (MR), yet the mechanisms of their crosstalk remain unclear. This study used bioinformatics ... read more

Inflammatory-neurodegenerative crosstalk in pediatric severe traumatic brain injury: a multi-domain plasma proteomic study.

Molecular medicine (Cambridge, Mass.) May 14, 2026

BACKGROUND: Pediatric severe traumatic brain injury (sTBI) remains a leading cause of death and long-term disability, yet its molecular characterization is incomplete. Single-biomarker approaches fail to capture the biological heterogeneity underlyin... read more

Single-cell and machine learning reveal ROS-associated heterogeneity in hepatocellular carcinoma for precision medicine.

BMC cancer May 14, 2026

BACKGROUND: Reactive oxygen species (ROS) are critical regulators of tumor development and progression, yet their clinical significance and cellular mechanisms remain poorly defined in hepatocellular carcinoma (HCC). METHODS: A comprehensive computat... read more

Deep learning-based CT radiomics for ALK rearrangement status prediction in lung adenocarcinoma.

BMC cancer May 14, 2026

BACKGROUND: Current clinical guidelines mandate routine evaluation of anaplastic lymphoma kinase (ALK) rearrangement in lung adenocarcinoma prior to ALK-targeted therapy initiation. This study aimed to develop and validate a non-invasive predictive m... read more

Identifying frailty trajectories in older patients with acute myocardial infarction using structural entropy clustering: a prospective cohort study.

BMC geriatrics May 14, 2026

BACKGROUND: Frailty significantly complicates clinical outcomes in older adults with acute myocardial infarction, yet its progression is dynamic and heterogeneous. This study aimed to identify distinct frailty trajectory patterns and their predictors... read more

Comparative accuracy of a predictive algorithm versus cardiologist assessment for 90-day readmission in decompensated chronic heart failure.

BMC cardiovascular disorders May 14, 2026

BACKGROUND: Heart failure is a leading cause of hospital readmission globally. Few studies have compared the performance of artificial intelligence-based prediction models directly with expert clinical judgment. The objective was to compare the perfo... read more

Development and validation of a novel deep learning coronary artery plaque quantification model.

BMC medical imaging May 14, 2026

BACKGROUND: Coronary Computed Tomography Angiography (CCTA) is an established tool for assessing coronary artery disease. CCTA determined total coronary artery plaque volume predicts cardiovascular events, but manual quantification is impractical for... read more

An integrated multi-variable optimization approach to tailor ankle-foot orthosis stiffness to end-user needs.

Journal of neuroengineering and rehabilitation May 14, 2026

BACKGROUND: Ankle foot orthosis (AFOs) are devices commonly prescribed to assist or rehabilitate gait. A critical parameter influencing their effectiveness is the stiffness of the AFO. Although suppliers typically recommend stiffness levels based on ... read more

Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms.

Cancer cell international May 14, 2026

BACKGROUND: Liver hepatocellular carcinoma (LIHC) is a common malignancy, yet the core genes driving its progression and potential therapeutic targets remain insufficiently explored. Ribosome biogenesis (RB) is a critical biological process linked to... read more

Artificial Intelligence Medical Compendium