Visualizing genome organization and transcriptional dynamics with spatial and temporal precision in living cells is essential for elucidating gene regulation and chromatin-associated disease mechanisms, yet conventional methods confront a fundamental... read more
International journal of computer assisted radiology and surgery
May 13, 2026
PURPOSE: Internal anatomical motion challenges precise radiation delivery during external beam radiotherapy. Estimating and compensating for anatomical motion are essential for improving planned dose delivery to target volumes while sparing organs-at... read more
INTRODUCTION: Artificial intelligence (AI) and digital pathology have the potential to augment liver biopsy interpretation in MAFLD in clinical practice and trials assessment. However, attitudes and barriers to its implementation have not been system... read more
Despite the power of CRISPR in genome editing, its clinical application is limited by off-target effects; these effects are currently difficult to evaluate at the genome level but are likely to involve chromatin context. Here, we developed the Endoge... read more
Plasma metabolomics offers significant potential for non-invasive biomarker discovery in gastric cancer (GC), yet conventional analytical workflows face challenges in absolute quantification and biological interpretability, hindering clinical transla... read more
Paediatric cardiology presents challenges due to the rarity and complexity of conditions like congenital heart disease. Using retrospective electronic healthcare records from 1,522 Great Ormond Street Hospital cases, we benchmark machine learning mod... read more
Enzymes catalyze complex chemical transformations with remarkable efficiency and selectivity, yet their atomistic mechanisms remain challenging to capture because conventional simulations trade accuracy for efficiency. Here we introduce a reactive ma... read more
Rapid identification and localization of an acute coronary occlusion are vital to prevent myocardial damage, yet reliance on ST-segment ECG criteria misses many acute occlusion myocardial infarctions (OMI) and triggers unnecessary acute angiographies... read more
Glioblastoma is a highly aggressive primary brain tumor with near-universal recurrence despite maximal safe resection followed by standard chemoradiation. We conducted a prospective pilot study (ClinicalTrials.gov identifier: NCT03477513) with predef... read more
Brain tumors exhibit high heterogeneity in morphology, texture, and location, making accurate recognition and segmentation critical for clinical diagnosis, surgical planning, and prognosis evaluation. However, manual annotation of MRI scans is hinder... read more
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