Introduction: Infectious and wound-healing complications after colorectal surgery often increase the complexity of local care and the need for specialized enterostomal therapy follow-up after hospital discharge. Despite the growing use of predictive ... read more
Molecular conformations play a critical role in determining molecular properties, such as membrane permeability, binding affinity, and ultimately therapeutic efficacy. Experimental and computational approaches can characterize conformations and provi... read more
Tuberculosis (TB) continues to pose a significant global public health challenge with substantial morbidity and mortality. Current TB biomarkers lack sufficient resolution to inform treatment response and patient stratification. We previously demonst... read more
SummaryDNA methylation datasets from public repositories such as NCBI Gene Expression Omnibus are central to the development and evaluation of epigenetic aging clocks, yet existing resources and tools do not fully resolve the bottlenecks of dataset r... read more
The mechanical behavior of right ventricular (RV) myocardium is governed by its anisotropic microstructure, yet constitutive models that account for fiber dispersion and enable reliable parameter identification remain limited. In this study, we propo... read more
The immense value of public gene expression repositories is constrained by the lack of compatibility among datasets generated from diverse experimental technologies. Differences in measurement scales, probe chemistries, and signal distributions creat... read more
Abstract: Image-based liver Couinaud segmentation is designed to automatically provide the locations of suspicious objects in liver CT/MR images. Once achieved, the physicians will be guided to the target slice and area where the suspicious node is l... read more
Drug repurposing offers a cost-effective strategy to accelerate therapeutic discovery, but most computational approaches fail to model noncoding genetic variation. Because over 90% of genome-wide association study (GWAS) risk variants reside in nonco... read more
Cerebellar neural circuit dynamics rely on a rich repertoire of synaptic and excitability mechanisms, which are thought to determine network computation in physiological and pathological conditions. In this work, we develop and validate a biologicall... read more
Membrane transport is a fundamental biological process with profound implications for pharmacology, biotechnology, and microbiology. While computational approaches have largely adopted a protein-centric perspective to annotate transportomes, inferrin... read more
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.