Deep learning approaches have revolutionized protein structure prediction. These tools are trained using experimental data and recapitulate reported conformations, but there is great interest in predicting conformations that may be functionally relev... read more
Alignment-based detection of transposable element (TE) insertion polymorphisms suffers from reference bias and multi-mapping errors in repetitive genomic regions, creating a fundamental validation bottleneck for population-scale structural variant ca... read more
The geometry of representations learned by deep neural networks is shaped jointly by architecture and pretraining objective, yet disentangling these two factors remains difficult. Here we isolate the contribution of pretraining objective by comparing... read more
Computational models are a linchpin in our understanding of the neurocognitive basis of reading. These models can simulate idealized profiles of alexia syndromes, but in reality, individuals with alexia present with a wide range of mixed deficits rat... read more
Learning interpretable low-dimensional representations of whole-brain neuronal dynamics remains a major computational challenge in systems neuroscience. We present a wiring-agnostic deep-learning framework that couples a convolutional encoder with a ... read more
Metagenomic assembly can be a computationally intensive step in microbiome analysis, with memory requirements that vary widely depending on input data characteristics. In workflow systems like Galaxy and large-scale platforms like MGnify, which run t... read more
Inference of cancer cell states is essential for understanding oncogenic mechanisms and predicting clinical outcomes, yet current reliance on transcriptomic profiling limits scalability and real-time monitoring. Here, we show that cell morphology pro... read more
Human behavioral and mental health outcomes arise from interactions among genetic, environmental, and neurobiological systems. Existing frameworks often model these components jointly, but many treat variables independently or use static representati... read more
The Post-baccalaureate Research Education Program (PREP), established by the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health in 2000, was a research-intense, one-year training program for recent college gra... read more
The spatial organization of proteins within cells governs virtually all cellular functions. Yet, current imaging technologies can simultaneously visualize only tens of proteins, orders of magnitude below the thousands that populate a single human cel... read more
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.