In task-oriented teams, long-term coordination among specialized roles may contribute to shared patterns of cognition and behavior, yet little is known about how such experience is reflected in brain functional organization. Here, we examined whether... read more
Selecting the correct mouse gene to model a human disease phenotype is critical for translational research, yet sequence-based orthology can fail when genes have been lost, duplicated, or functionally rewired between species. Here we present BRIDGE (... read more
Convolutional Neural Networks (CNNs) have become increasingly prominent in biodiversity monitoring due to their strong performance in accurately detecting species from sound recordings, overcoming some limitations of traditional methods such as point... read more
Rapid and accurate prediction of protein-ligand bindings is essential for drug discovery. While generative AI has driven rapid advancements in structure-based approaches, sequence-based methods remain significantly faster and more cost-effective. Her... read more
Explainable machine learning (ML) methods are gaining increasing attention in environmental and ecological research for their ability to reveal relationships between environmental drivers and population dynamics. However, there remain questions on th... read more
Constraint-based metabolic modeling is a powerful way to study the mechanistic basis of cellular states and disease, but its effective use demands substantial computational expertise and careful coordination of multi-step analyses. We developed MechA... read more
Deep learning approaches have revolutionized protein structure prediction. These tools are trained using experimental data and recapitulate reported conformations, but there is great interest in predicting conformations that may be functionally relev... read more
Alignment-based detection of transposable element (TE) insertion polymorphisms suffers from reference bias and multi-mapping errors in repetitive genomic regions, creating a fundamental validation bottleneck for population-scale structural variant ca... read more
The geometry of representations learned by deep neural networks is shaped jointly by architecture and pretraining objective, yet disentangling these two factors remains difficult. Here we isolate the contribution of pretraining objective by comparing... read more
The spatial organization of proteins within cells governs virtually all cellular functions. Yet, current imaging technologies can simultaneously visualize only tens of proteins, orders of magnitude below the thousands that populate a single human cel... read more
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