The US Food and Drug Administration (FDA) maintains a public list of artificial intelligence and machine learning (AI/ML)-enabled medical devices that have received marketing authorization. Prior published analyses examined this list at earlier time ... read more
Multi-organ biological aging is often represented as parallel organ-specific clocks, but how age gaps should be interpreted within an anatomically coupled imaging system remains unclear. Applying end-to-end deep learning to abdominal Dixon MRI from 6... read more
Menopause affects over one billion women worldwide, yet remains poorly characterized at scale. We apply an ICD-10-based phenotyping algorithm to electronic health records (EHR) from an academic medical center (n=33,444 women aged 35-64) and a safety-... read more
Machine learning (ML) holds great promise to support, improve, and automatize clinical decision-making in hospitals. Data protection regulations, however, hinder abundantly available routine data from being shared across sites for model training. Gen... read more
Deep learning-based facial phenotyping represents a major paradigm shift in the diagnosis of rare and ultra-rare genetic disorders. By capturing disease-specific craniofacial 'gestalts' that are often subtle, overlapping, but overlooked in routine cl... read more
While RNA language models (LMs) have served as foundation models (FMs) to advanced structural prediction, their evaluation relies heavily on supervised downstream tasks. Such tasks can often mask FM inefficiencies and reflect downstream training set ... read more
Accurate selection of start codons by ribosomes is a fundamental determinant of proteome composition. Although the 'Kozak sequence'--an 8-nucleotide sequence flanking the start codon--has long been viewed as the primary determinant of initiation in e... read more
Spontaneous thought is pervasive in everyday human cognition, yet datasets capturing its neural dynamics under minimally interrupted conditions remain limited. The current dataset was acquired from a think-aloud functional MRI experiment in which 118... read more
Drug-induced inhibition of the hERG potassium channel is the leading cause of cardiac safety-related drug attrition, but the Comprehensive in Vitro Proarrhythmia Assay (CiPA) framework requires activity data on multiple cardiac ion channels to assess... read more
The application of artificial intelligence to biomedical research increasingly depends on iterative cycles in which AI systems analyze experimental data, propose follow-up conditions, and drive automated execution at scale, a paradigm central to Bio-... read more
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