Artificial Intelligence Medical Compendium

Explore the latest research on artificial intelligence and machine learning in medicine.

Showing 19,911 to 19,920 of 215,899 articles

Cyst-type epithelial heterogeneity shapes therapeutic responsiveness in ADPKD

bioRxiv May 12, 2026
Autosomal dominant polycystic kidney disease (ADPKD) exhibits substantial interpatient variability in disease course and therapeutic response, but the cellular basis for this variability remains poorly understood. Here, we combine single-nucleus RNA ... read more 
molecular biology

Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response

bioRxiv May 12, 2026
Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus (SLE), features heterogeneous renal pathology and reliance on invasive biopsies for diagnosis, prognosis, and treatment selection. Current peripheral clinical markers inadeq... read more 
immunology

Integrative Genomic, Single-Cell, and Functional Profiling of the CD48-CD244 Axis and NK-Cell Dysfunction in Multiple Myeloma

bioRxiv May 12, 2026
Multiple myeloma (MM) orchestrates immune evasion by subverting natural killer (NK) cell function. CD48, one of the most abundant NK-ligands on MM cells, paradoxically enhances NK-cell activation yet is associated with high-risk cytogenetics and poor... read more 
cancer biology

Predicting curvature evolution on biological surfaces from clinical imaging-derived area dilation: a closed-form interpretable framework

bioRxiv May 12, 2026
Curvature evolution on a deforming surface is governed by the full change in the surface metric, but on biological surfaces captured by serial three-dimensional imaging, only the local area change is observable. The loss of the shear component leaves... read more 
bioengineering

Machine Learning Analysis to Define Cell Lineage in Leiomyosarcoma

bioRxiv May 12, 2026
Introduction Cellular differentiation and lineage commitment are known to be associated with differences in DNA methylation. Leiomyosarcoma (LMS) is a tumor thought to originate from smooth muscle cells in the walls of vessels in the soft tissue (STL... read more 
cancer biology

Kinome profiling allows examination and prediction of kinase inhibitor cardiotoxicity

bioRxiv May 12, 2026
Background: Despite improved cancer outcomes with kinase inhibitors (KIs), their cardiotoxicity remains a significant clinical challenge. Current approaches to predict and prevent KI-induced cardiac adverse events (CAEs) are limited by an incomplete ... read more 
systems biology

A CBF-SA module links wound-induced evaporative cooling to tissue repair in plants

bioRxiv May 12, 2026
Repairing damaged tissues is essential for the survival of all organisms. In plants, tissue injury rapidly triggers defense and repair programs. However, the molecular mechanisms linking early injury cue to the later stages of wound repair remain unc... read more 
plant biology

Unifying the Electron Microscopy Multiverse through a Large-scale Foundation Model

bioRxiv May 12, 2026
Accurate analysis of electron microscopy (EM) images is essential for exploring nanoscale biological structures, yet data heterogeneity and fragmented workflows hinder scalable insights. Pretrained on large, diverse datasets, image foundation models ... read more 
bioengineering

Transferable Transcriptional Topic Modeling Traces Medulloblastoma Subtypes to Distinct Cerebellar Developmental States

bioRxiv May 12, 2026
Single-cell transcriptomics transformed our understanding of cellular heterogeneity, yet cross-dataset comparison remains fundamentally limited by batch effects, technology differences, and inconsistent annotation frameworks. These challenges have im... read more 
bioinformatics

Thrombospondin-2 is a performant biomarker of at-risk MASH and advanced MASH fibrosis in a large multicentre European cohort.

Gut May 12, 2026
BACKGROUND: Non-invasive biomarkers with biological rationale are needed for identifying patients with progressive metabolic dysfunction-associated steatohepatitis (MASH). OBJECTIVE: To test the diagnostic performance of thrombospondin-2 (TSP2), insu... read more 
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