ABSTRACT Background The clinical assessment of knee stability after an Anterior Cruciate Ligament (ACL) injury is routinely conducted via operator-dependent physical examination tests (i.e. pivot shift) and standardized patient-reported outcomes. Unf... read more
Purpose: In this study, we aimed to develop and evaluate an artificial intelligence-based diagnostic model for the diagnosis of acute cholecystitis (AC) using non-contrast CT images and clinical data. Materials and Methods: This retrospective study i... read more
Transmissible hospital-acquired infections (HAIs) arise from complex, time-varying interactions among patients, healthcare workers, and clinical environments. Although data-driven approaches like graph neural networks (GNNs) effectively model these c... read more
The US Food and Drug Administration (FDA) maintains a public list of artificial intelligence and machine learning (AI/ML)-enabled medical devices that have received marketing authorization. Prior published analyses examined this list at earlier time ... read more
Multi-organ biological aging is often represented as parallel organ-specific clocks, but how age gaps should be interpreted within an anatomically coupled imaging system remains unclear. Applying end-to-end deep learning to abdominal Dixon MRI from 6... read more
Menopause affects over one billion women worldwide, yet remains poorly characterized at scale. We apply an ICD-10-based phenotyping algorithm to electronic health records (EHR) from an academic medical center (n=33,444 women aged 35-64) and a safety-... read more
Machine learning (ML) holds great promise to support, improve, and automatize clinical decision-making in hospitals. Data protection regulations, however, hinder abundantly available routine data from being shared across sites for model training. Gen... read more
Deep learning-based facial phenotyping represents a major paradigm shift in the diagnosis of rare and ultra-rare genetic disorders. By capturing disease-specific craniofacial 'gestalts' that are often subtle, overlapping, but overlooked in routine cl... read more
Background: Despite improved cancer outcomes with kinase inhibitors (KIs), their cardiotoxicity remains a significant clinical challenge. Current approaches to predict and prevent KI-induced cardiac adverse events (CAEs) are limited by an incomplete ... read more
Drug-induced inhibition of the hERG potassium channel is the leading cause of cardiac safety-related drug attrition, but the Comprehensive in Vitro Proarrhythmia Assay (CiPA) framework requires activity data on multiple cardiac ion channels to assess... read more
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