Repairing damaged tissues is essential for the survival of all organisms. In plants, tissue injury rapidly triggers defense and repair programs. However, the molecular mechanisms linking early injury cue to the later stages of wound repair remain unc... read more
Single-cell transcriptomics transformed our understanding of cellular heterogeneity, yet cross-dataset comparison remains fundamentally limited by batch effects, technology differences, and inconsistent annotation frameworks. These challenges have im... read more
Objective: How structured clinical features and cluster-semantic embeddings interact under self-distillation in EHR prediction models is unknown. Existing approaches treat these sources separately (gradient-boosted trees exploit tabular features whil... read more
A key question in cell biology is how cell-scale organization emerges from a given set of molecular players and rules of interaction. Given its multiscale nature, addressing this question requires a combination of experimental perturbation, mathemati... read more
Drug-induced arrhythmias, particularly Torsades de Pointes (TdP), pose a significant risk to patient safety and can sometimes have life-threatening outcomes. They remain a major concern in drug development and regulation. Machine learning (ML) has be... read more
Quantitative Systems Pharmacology (QSP) models play an inherently interventional role in pharmaceutical research and development, functioning as executable causal systems for designing, evaluating, and replacing clinical trials. However, deploying QS... read more
Diffusion MRI (dMRI) tractography provides a non-invasive method for mapping whole-brain structural connectivity. However, its application is limited by substantial false-positive and false-negative connections. While deep learning based methods have... read more
Three-dimensional (3D) whole-organ imaging and analysis at cellular resolution (termed 3D histology) provide profound insights into the organization and interactions of cells throughout organs. However, the quantitative analysis of these massive data... read more
Tandem mass spectrometry (MS/MS) fragments molecules into smaller pieces, generating spectra composed of m/z values and intensities that encode structural information for molecular annotation. With increasing mass spectrometry data acquisition speeds... read more
Metagenomic sequencing generates petabyte-scale sequence datasets that strain both deep learning and alignment based enzyme annotation tools. A lightweight rapid and accurate filter tool is needed to identify enzymatic sequences prior to resource-int... read more
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