Motivation: Protein melting temperature (Tm) prediction accelerates the discovery of thermostable enzymes which are crucial for industrial biotechnology often requiring harsh reaction conditions. Experimental determination of Tm remains labour-intens... read more
Motivation: Accurately modelling how microbial communities assemble and change across hosts and environments is essential for analysis and intervention. Typical pipelines capture limited generalisable structure and often depend on fixed ecological un... read more
Tissue homeostasis and disease emerge from cell-cell interactions operating across spatial scales: from autocrine and juxtacrine signals within micrometers to paracrine gradients coordinating responses across tissues. While these can be read out from... read more
Regulation of RNA subcellular localization is crucial for cellular functions in health and disease. For example, local translation of co-localized RNAs is crucial for neural biology. However, it is challenging to identify RNA co-localization events. ... read more
The human microbiome is a critical determinant of health and disease, but microbiome machine learning is constrained by limited data availability, heterogeneous cohort coverage, and privacy risks from individually identifying microbial signatures. Sy... read more
Developing sensory systems may have heightened sensitivity to exaggerated features that emphasize diagnostic information, as shown by the benefits of infant-directed speech for language acquisition. Here, we examine this sensory exaggeration hypothes... read more
In vitro selection and directed evolution technologies such as mRNA display, explore large libraries (10^14 variants) and generate thousands to millions of functional polypeptide ligands to a variety of targets. Denoising diffusion implicit machine l... read more
Pattern formation underlies biological organization across scales, but predicting experimentally observed patterns remains difficult because mechanistic models and data-driven generative models fail in complementary ways. Coarse-grained mechanistic m... read more
Working memory (WM), the human brain's system for maintaining and manipulating information over short timescales, is critical for goal-directed behavior. Classic neurophysiological models, which emphasize persistent delay activity, are being challeng... read more
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