Hypercholesterolemia is a pivotal risk factor for cardiovascular diseases, and its effective management is critical to reducing cardiovascular event incidence. The protein-protein interaction (PPI) between PCSK9 and low-density lipoprotein receptor (... read more
Supramolecular complexes of volatile components and cyclodextrin are widely used to improve the stability of volatile compounds. However, the quality assessment of these complexes remains challenging. In this study, paeonol/cyclodextrin complexes wer... read more
Dengue is a major mosquito-borne viral disease with no effective antiviral treatment currently available. This work introduces a machine-learning framework to predict anti-dengue activity in small molecules using Atomic-Weighted Vector (AWV) descript... read more
BACKGROUND: Lung squamous cell carcinoma (LUSC) exhibits poor prognosis and a highly complex tumor immune microenvironment (TIME), creating an urgent clinical need for novel biomarkers to guide personalized treatment. Although kinase-related genes (K... read more
Aging clinical and experimental research
May 9, 2026
A growing body of research is focusing on how music, technology, and neuroscience can converge to promote healthy ageing and counteract pathological decline. In particular, music interventions for older adults have been garnering increasing attention... read more
BACKGROUND: Imbalance in gut microbiota (GM) may play a role in the development of thyroid cancer (TC), but the specific mechanisms remain unclear. This study aimed to identify prognostic genes associated with both TC and GM and investigate the under... read more
OBJECTIVE: In positron emission tomography (PET)/magnetic resonance imaging (MRI), attenuation correction (AC) for PET of the head is achieved by MRI data to generate pseudo-computed tomography (CT) images. However, for the torso, AC becomes more cha... read more
MOTIVATION: Accurate prediction of HIV drug resistance from viral sequences is critical for optimising antiretroviral therapy. Traditional machine-learning approaches using binary mutation encoding achieve strong accuracy but may fail to capture epis... read more
3D human body modelling offers new opportunities for advancing ergonomic assessment in clothing design, particularly in evaluating fit, comfort, and human-garment interaction. This paper provides a systematic review of recent developments in 3D body ... read more
Large language models (LLMs) have recently gained attention for their potential. However, concerns remain regarding their reliability due to limitations such as hallucinations and insufficient domain-specific knowledge. Retrieval-augmented generation... read more
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