Machine learning continues to accelerate peptide and protein design through the rapid prediction and generation of sequences with desired characteristics. Many applications focus on predicting properties, functions, and structures, as well as generat... read more
Large language models are increasingly used as scientific agents, yet the flexibility that benefits general-purpose agents can conflict with the accountability required in biomedical research. We study whether biomedical agents can be organized aroun... read more
G-quadruplex (G4) prediction has been largely guided by in vitro biophysical rules, yet these models show limited agreement with in vivo measurements. Here, we present QuadStack, a deep learning model trained on a multi study BG4-ChIP-seq compendium.... read more
The automated classification of animals from photos is important in ecology and conservation biology for organizing and understanding the immense diversity of species, as well as facilitating effective conservation and management practices. It is equ... read more
Large language models (LLMs) are increasingly deployed as agents for scientific discovery, but standardized frameworks for evaluating their performance and behaviour in scientific workflows are lacking. Protein design provides a demanding test case b... read more
The sense of smell remains poorly understood, especially in contrast to visual and auditory coding. At the core of our sense of smell is the olfactory information flow, in which odorant molecules activate a subset of our olfactory receptors and combi... read more
The neuromodulator acetylcholine has been suggested to govern learning under uncertainty. Here, we investigated the role of muscarinic acetylcholine receptors in reward-guided learning and decision making under different degrees of uncertainty. We ad... read more
Predicting transitions between health, disease, and death across biological systems remains an important challenge with significant implications for both ecological management and medical intervention. Although the principles underlying these transit... read more
Clinical adoption of machine learning (ML) in medical imaging is limited by the lack of interpretability. To address this, we present understandable post-hoc artificial intelligence reports (UPhAIR), a pipeline designed to generate transparent, evide... read more
Introduction: Adolescents with mental health disorders represent a vulnerable group with complex care needs, yet their and their relatives experiences in acute inpatient mental health services remain poorly understood. While patient-reported experien... read more
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