Endogenous peptides are critical regulators of signaling and immunity but remain difficult to characterize in organisms with incomplete genomic annotation. We developed a hybrid discovery platform that integrates transformer-based de novo sequencing ... read more
Medical imaging models depend on large, shareable datasets, yet privacy constraints limit data dissemination. Current text-conditioned diffusion models fail to preserve subtle, distributed clinical signals, such as continuous physiological biomarkers... read more
Early management decisions in operational forestry are critical for plantation success because it strongly influences seedling quality at planting. Beyond shaping seedling morphology, nursery inputs can also restructure root-associated fungal communi... read more
Biomarkers in sweat and saliva offer a promising avenue for non-invasive health monitoring. Electrochemical sensors have the potential to measure such biomarkers simultaneously. However, they are limited in discriminating individual biomarkers in mix... read more
Quantum kernel methods offer a potential advantage for classification tasks in high-dimensional feature spaces, yet their practical benefit critically depends on how input features are prepared. We compare five dimensionality reduction strategies - p... read more
Short linear motifs (SLiMs) are short (3-15 amino acids in length) segments within intrinsically disordered regions (IDRs) that mediate transient protein-protein interactions as well as other functions such as stability and subcellular localization. ... read more
Understanding the pathogenesis of amyloid-{beta} pathology in Alzheimer's Disease (AD) proves to be a challenge. In this work, we expand upon the application of network diffusion models (NDM) to study pathophysiological spread of amyloid-{beta} throu... read more
The learning dynamics of biological brains and artificial neural networks are of interest to both neuroscience and machine learning. A key difference between them is that neural networks are often trained from a randomly initialized state whereas eac... read more
Treponema pallidum ssp. pallidum, the causative agent of syphilis, has a small proteome and encompasses numerous strains. Knowledge gaps remain in understanding the molecular mechanisms of pathogenesis of this bacterium, as well as the structure and ... read more
Artificial intelligence has advanced from analyzing experimental data to autonomously generating hypotheses, designing experiments, and coordinating closed loop discovery. Yet the translation from computational reasoning to physical execution remains... read more
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.