AI Medical Compendium

Actually, what is a gain-of-function mutation?

Genetics May 6, 2026

For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scientists-always on the lookout for general principles-have categorized these mutations, hoping that putting ... read more

Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology.

The Biochemical journal May 6, 2026

Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is an established technique that measures the exchange rate of amide hydrogens, with this exchange rate being a surrogate for protein conformational dynamics. Advances in instrumentation, automat... read more

Preparation and motion study of a micro soft robot mimicking the cownose ray driven by external magnetic field.

Bioinspiration & biomimetics May 6, 2026

In narrow, unstructured underwater environments such as target monitoring and minimally invasive medical procedures, micro soft robots exhibit unique advantages due to their flexible movement capabilities and small size. At the same time, bionic desi... read more

Large language models for deductive qualitative content analysis in dementia-focused embedded pragmatic clinical trials: A comparative methodological study.

Implementation science communications May 6, 2026

INTRODUCTION: Thematic coding helps researchers characterize intervention implementation in embedded pragmatic clinical trials (ePCTs), particularly interventions for older adults with dementia and care partners. However, manual coding is time-consum... read more

From Anger Detection to Intensity Modeling: A Two-Stage Machine Learning Approach Using Driving Performance and Physiological Signals.

IISE transactions on occupational ergonomics and human factors May 6, 2026

OCCUPATIONAL APPLICATIONSThis study demonstrated that driver anger can be feasibly modeled across three intensity levels using combined driving performance metrics and physiological signals. A two-stage machine learning framework, which first determi... read more

Genetics of bipolar disorder: Translating discoveries to biological insights and clinical decision support.

Psychiatry and clinical neurosciences May 6, 2026

Bipolar disorder (BD) is a clinically heterogenous mental disorder with a diversity in clinical trajectories and treatment response. Twin studies have shown that BD is highly heritable, with estimates ranging from 60% to 90%. However, our understandi... read more

Sad but true: how emotions and political ideology shape perceptions of information.

Cognition & emotion May 6, 2026

Political and economic challenges, amplified by social media algorithms, are increasingly polarising how people receive and evaluate information. This study examines how political views and immediate emotional reactions shape the perceived trustworth... read more

Expanding the Therapeutic Window in Oncology: Modern Strategies and Future Directions.

Cancer biotherapy & radiopharmaceuticals May 6, 2026

Background:The enhancement of the therapeutic window (TW) in oncology remains a significant challenge, as the majority of anticancer treatments face difficulties in achieving optimal tumor control while minimizing adverse effects. Traditional chemoth... read more

Predicting and Decoding Allosteric Binding Sites Using Protein Language Models and Structure-Based Machine Learning: An Energy Landscape-Guided Explainable AI Framework.

Journal of chemical theory and computation May 6, 2026

Computational prediction of allosteric binding sites in protein structures remains a persistent challenge, as these regulatory pockets evade detection by both sequence-based and structure-based algorithms. Both computational and physical origins of t... read more

Photophysics and complexation of indolic compounds: the effect of intra-annular and extra-annular substitution.

Physical chemistry chemical physics : PCCP May 6, 2026

In this work, substitution-dependent modulation of ground- and excited-state properties is examined for intra-annular aza-substituted indoles (indazole, benzimidazole, and benzotriazole) and extra-annular C5-substituted derivatives (CN, COOH, CHO, F,... read more

Artificial Intelligence Medical Compendium