Disease is a heterogeneous process that involves multiple organs and cell types. Understanding how genomic variation contributes to disease requires approaches that move beyond the linear assumptions of additive models and resolve underlying disease ... read more
Staphylococcus aureus produces a broad range of enterotoxins that act as superantigens, disrupting host immune responses and resulting in a myriad of clinical symptoms. However, large-scale analyses determining enterotoxin gene diversity, lineage str... read more
Despite the breakneck pace of progress in protein design methodology, frontier problems remain challenging, with leading methods struggling to design high-affinity binders, scaffold multiple functional motifs, or stabilize large multi-domain proteins... read more
Fast extraction of physically relevant information from images using deep neural networks has led to significant advances in fluorescence microscopy and its application to the study of biological systems. For example, the application of deep networks... read more
Spatial transcriptomics analysis often involves a myriad of computational methods across diverse platforms, leading analysts to spend excessive time on data assembly rather than deriving biological insights. Current AI solutions tend to either oversi... read more
Making decisions in complex, real-world environments is challenging. Biologically plausible strategies like reinforcement learning (RL) require attention toward reward-predictive stimuli to define task states, yet how attention and decision processes... read more
Accurate gene annotation is crucial for inference of biological knowledge from genomes. However, non-canonical genes such as orphan or single-exon genes as well as those residing in rapidly evolving regions are routinely dismissed in annotation pipel... read more
Chimeric Antigen Receptor T-cell (CAR-T) therapy, where genetically engineered patient T cells target tumor antigens, has transformed care for hematologic malignancies but requires careful tracking of adverse events (AEs) often documented only in uns... read more
Pre-visit planning has the potential to reduce EHR documentation burden while improving workflow efficiency, care quality, and patient-provider engagement. Large language model (LLM) chatbots show promise for supporting this task, but while their Eng... read more
Early detection of Rheumatic Heart Disease (RHD) is essential in reducing its associated mortality and late complications. In resource-limited settings, automated detection using low-cost electrocardiogram (ECG) sensors can enhance prevention efforts... read more
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