Background: Machine learning models for intensive care unit (ICU) mortality prediction achieve strong internal discrimination yet rarely undergo external validation with calibration assessment - a gap undermining clinical deployment. Calibration, the... read more
Severe fetal growth restriction (sFGR) affects 5 to 10% of pregnancies worldwide and is a major contributor to perinatal morbidity and mortality, particularly in low- and middle-income countries (LMICs). Traditional 2D ultrasound detection methods su... read more
Emergency department (ED) triage assigns patients a five-level Emergency Severity Index (ESI) score that determines care priority. We investigate the feasibility of au- tomating this process, comparing large commercial models (GPT-4o, Claude 3.5 Sonn... read more
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with particularly severe consequences in sub-Saharan Africa where access to advanced diagnostic imaging remains limited. Ultrasound is the most widel... read more
Most clinical trials fail due to either lack of efficacy or safety concerns. Human genetics can address both failure reasons: disease-associated genes are not only promising therapeutic targets but also predict drug side effects. However, because the... read more
We present a digital twin framework for real time glucose monitoring and forecasting in septic patients in intensive care units (ICUs). The framework combines advanced machine learning models trained on continuous glucose measurements with a dynamic ... read more
Purpose: Assessing visual function in patients with ultra-low vision (ULV), particularly those with retinitis pigmentosa (RP), remains a significant challenge in therapeutic development. Full-field stimulus test (FST) provides a quantitative measure ... read more
Frequent HIV testing, or "retesting," the practice of regular HIV testing following a negative test result, among persons at high risk of HIV exposure is critical for initiating treatment early among newly infected persons and reducing the risk of HI... read more
Since the release of the first ChatGPT model in 2022, large language models (LLMs) have evolved significantly, and an increasing number of users now turn to these generative information systems for inquiries as sensitive and consequential as those re... read more
Objectives This study aimed to develop and validate machine learning models to predict in-hospital mortality among systemic lupus erythematosus (SLE) patients using administrative claims data in a tertiary referral center in Indonesia. Methods We con... read more
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