High-throughput accurate protein-protein interaction (PPI) prediction is foundational to systems-level biological understanding, disease mechanism dissection, and structure-based drug discovery. Traditional graph convolutional networks (GCNs) are lim... read more
Learning causal gene regulatory mechanisms from single-cell data, and thereby predicting the effects of unseen perturbations, remains challenging. Observational RNA-seq data alone is insufficient for causal modeling, whereas perturbational data is es... read more
To comprehend language, the brain must navigate a high-dimensional semantic landscape while seamlessly contextualizing meaning. Inspired by recent advances in the mechanistic interpretability of large language models (LLMs), we hypothesized that the ... read more
Understanding how nervous systems generate coordinated movement requires precise measurement of body kinematics during natural behavior. The fruit fly, Drosophila, is a model organism with sophisticated behavior and well-studied neural circuits, but ... read more
Artificial intelligence (AI) systems such as AlphaFold have transformed structural biology by enabling accurate prediction of protein structures. However, their capacity to uncover new classes of macromolecular assemblies remains largely untapped. We... read more
Neuronal shape determines how neurons process and integrate information, yet a consistent and objective classi cation of neuronal morphologies remains elusive. Current approaches rely heavily on subjective expert views or on prede ned features, limit... read more
The widespread adoption of machine learning in critical applications demands techniques to mitigate high-consequence errors. Our method utilizes a dual-classifier GBDT pipeline to distinguish routine human-like errors from high-risk non-human misclas... read more
Chemotherapy dose optimization can be formulated as a dynamic treatment regime, requiring sequential decisions under uncertainty that must balance tumor suppression against toxicity. However, most reinforcement learning approaches assume full observa... read more
The rapid advancement of generative Artificial Intelligence (AI) has introduced significant challenges for reliable AI-generated image detection. Existing detectors often suffer from performance degradation under distribution shifts and when encounte... read more
Text-to-image diffusion models have revolutionized image synthesis and editing, but precise control over stylistic attributes remains a challenge, often causing unintended content modifications. We propose an approach for fine-grained parametric cont... read more
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