A generalization of the classical concordance correlation coefficient (CCC) is considered under a three-level design where multiple raters rate every subject over time, and each rater is rating every subject multiple times at each measuring time poin... read more
BACKGROUND: Melanoma represents a highly aggressive and metastatic form of malignant skin cancer. that remains challenging to treat clinically. Tumor cells often reprogram nicotinamide adenine dinucleotide (NAD⁺) metabolism to meet the demands of rap... read more
Academic burnout is a prevalent concern with significant implications for adolescent development, whereas variable-centered approaches often provide limited insight into its multi-ecological heterogeneity. This study combines machine learning (ML) wi... read more
The rapid integration of artificial intelligence (AI) into higher education is producing divergent learning behaviors, as student AI anxiety appears to both hinder and motivate learning. However, the psychological mechanisms that explain why these di... read more
INTRODUCTION: Circadian rhythm disruption (CRD) is a major driver of immune dysregulation; however, whether CRD promotes ischemic stroke (IS) progression through immune imbalance and the underlying molecular mechanisms remain unclear. METHODS: Transc... read more
Reliable prediction of Faecal Indicator Organisms (FIOs) in coastal bathing waters remains a major challenge because FIO concentrations could vary rapidly with the flow, meteorological, and hydrological conditions. Mechanistic models require high com... read more
OBJECTIVES: Diagnostic delay in Crohn's disease (CD) may increase the risk of poor prognosis. This study developed and validated a machine learning (ML) model for clinicians to conduct preliminary diagnosis and refer suspected patients. STUDY DESIGN:... read more
Since the emergence of synthetic biology, biofoundries have developed as enabling infrastructures that scale engineering biology globally. Landmark initiatives, such as Genome Project-Write, JCVI-syn3.0, Sc2.0, SynMoss and the Synthetic Human Genome ... read more
BACKGROUND: Artificial intelligence (AI) platforms are becoming increasingly popular as resources for equine information. However, these platforms generate responses from a wide range of sources and do not always distinguish between fact and opinion.... read more
Marine microalgae are frequently promoted as sustainable biofuel feedstocks because of their halotolerance, high photosynthetic efficiency, and limited land requirements, yet commercial deployment remains elusive. This gap is primarily systemic rathe... read more
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