Vaccine strain selection for seasonal influenza A(H3N2) depends on knowing which hemagglutinin (HA) substitutions are most likely to erode neutralizing antibody recognition, yet published antigenic site sets disagree substantially on which positions ... read more
The emerging field of artificial intelligence for neuroscience relies heavily on high-quality, standardized datasets. Data linking high-dimensional neural population dynamics with complex behavior is crucial for advancing the field of brain-computer ... read more
Proteins are highly diverse functional polymers where the specific sequence of amino acids, selected from a standard genetically-encoded alphabet of twenty (C20), determines the structure and ultimately the function of the resulting folded protein. T... read more
Accurate RNA secondary-structure prediction remains difficult despite decades of thermodynamics-based algorithms and the advent of deep-learning architectures (convolutional networks, Transformers, diffusion models). In fact, the datasets that pair R... read more
Prior expectations guide sensorimotor behavior when sensory information is uncertain, yet the cellular mechanisms underlying this integration remain elusive. Here, we investigate how priors in sensory motion direction shape neural population dynamics... read more
Precision medicine requires understanding the underlying drivers of heterogeneous treatment responses. Although machine learning methods have shown promise for estimating patient-specific treatment effects, their clinical utility remains limited beca... read more
Background: Electronic health records (EHRs) with clinical decision support tools are now ubiquitous in healthcare organizations. Clinical foundation models (CFMs) pretrained on large-scale, heterogeneous structured EHR data have emerged as a powerfu... read more
BACKGROUND: Aortic dissection (AD) is a life-threatening emergency with high mortality. Although elevated body mass index (BMI) is associated with both AD incidence and mortality, the underlying mechanisms remain unclear. Periaortic adipose tissue (P... read more
Caesarean section rates in Nigeria remain suboptimal, with significant disparities across socioeconomic and geographic strata. The objective of this research is to identify and characterize distinct obstetric risk profiles associated with caesarean s... read more
Randomized controlled trials (RCTs) provide high internal validity but often rely on restrictive eligibility criteria that limit generalizability and complicate real-world trial emulation. We propose AERO (AI Agent for Adaptive Eligibility Refinement... read more
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