Parkinson's disease (PD) is marked by progressive neurodegeneration in the substantia nigra (SN). This study evaluated deep-learning saturation-transfer magnetic resonance fingerprinting (ST-MRF) to quantify molecular and microstructural changes in P... read more
BACKGROUND: Current classifications used for total knee arthroplasty (TKA) are static and fail to capture the dynamic behavior of the limb during gait. This study introduces a novel intraoperative method to measure dynamic hip-knee angle (dHKA) using... read more
Wastewater treatment plants operate under highly variable influent conditions, challenging process control and regulatory compliance. This study proposes a machine learning framework based on threshold artificial neural networks optimised with geneti... read more
European journal of medicinal chemistry
Apr 30, 2026
Chemokine receptor 4 (CXCR4) is a clinically significant G protein-coupled receptor implicated in HIV-1 entry, cancer progression, immune regulation, and metastatic dissemination, making it an attractive therapeutic target. This study employed an int... read more
Journal of molecular graphics & modelling
Apr 30, 2026
Restoring the tumor-suppressor function of p53 by inhibiting its negative regulator, MDM2, represents a significant therapeutic avenue for cancers that maintain wild-type p53. This research aimed to identify new MDM2 inhibitors through a phylogenetic... read more
Metabolism: clinical and experimental
Apr 30, 2026
BACKGROUND AND AIMS: Age-related eye diseases (AREDs) share aging as a major risk factor, but the systemic molecular changes preceding disease onset remain incompletely understood. We aimed to define the shared and disease-specific immunometabolic ar... read more
Text-to-image diffusion models achieve impressive visual fidelity, yet they remain unreliable in multi-object generation. Despite extensive empirical evidence of these failures, the underlying causes remain unclear. We begin by asking how much of thi... read more
Event cameras provide several unique advantages over standard frame-based sensors, including high temporal resolution, low latency, and robustness to extreme lighting. However, existing learning-based approaches for event processing are typically con... read more
Real-world knowledge is often organized as hierarchies such as product taxonomies, medical ontologies, and label trees, yet learning hierarchical representations is challenging due to asymmetric structure and noisy semantics. We introduce Polaris, a ... read more
SAM2 produces high-quality zero-shot segmentation on natural images, but applying it to large remote sensing scenes exposes two problems: (1) its mask generator faces an inherent quality-coverage trade-off: strict thresholds yield precise masks but l... read more
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